Mouse Genome Informatics
ht
    Smad4tm1Mmt/Smad4+
B6.129S2-Smad4tm1Mmt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
digestive/alimentary system
• mutants older than 1 year develop inflammatory polyps in the duodenum
• mutants older than 1 year develop inflammatory polyps in the glandular stomach, often in the pyloric region
• polyps show Smad4 loss of heterozygosity

Mouse Models of Human Disease
OMIM IDRef(s)
Juvenile Polyposis Syndrome; JPS 174900 J:59214