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Phenotypes Associated with This Genotype
Genotype
MGI:2182801
Allelic
Composition
Smad4tm1Mmt/Smad4+
Genetic
Background
B6.129S2-Smad4tm1Mmt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm1Mmt mutation (0 available); any Smad4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mutants older than 1 year develop inflammatory polyps in the duodenum
• mutants older than 1 year develop inflammatory polyps in the glandular stomach, often in the pyloric region
• polyps show Smad4 loss of heterozygosity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
juvenile polyposis syndrome DOID:0050787 OMIM:174900
J:59214


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory