mortality/aging
• the 70% of mice that suffer from growth retardation and develop a wasting syndrome, typically die between 1 and 3 months of age
• remaining 30% die between 3 and 8 months of age with a similar wasting syndrome
|
growth/size/body
• 70% are smaller than wild-type prior to weaning
|
immune system
• neutrophils show impaired chemotaxis to TGF-beta
|
• symptomatic mutants have an involuted thymus
|
• T cells invade normal regions of B cell development and germinal center formation in lymph nodes
|
• lymph node T cells from enlarged submandibular and mesenteric lymph nodes exhibit an activated phenotype with an increased number of CD62L cells
|
• multifocal formation of pyogenic abscesses, which are most often periorbital, periodontal, and within the wall of the stomach and the intestine
|
• symptomatic mutants show a reduction in the cellularity of the thymus
|
• absolute increase in white blood cell counts
|
• increased numbers of circulating neutrophils
|
• increased numbers of circulating monocytes
|
small spleen
(
J:53510
)
• symptomatic mutants have a small spleen
|
• symptomatic mutants show a reduction in the cellularity of the spleen
|
• symptomatic mutants have enlarged lymph nodes
• mediastinal, mandibular and mesenteric lymph nodes are enlarged in the majority of mutants; nodes display lymphoid hyperplasia, with extensive proliferation of T cells and an accumulation of plasma cells, effacing the normal node architecture
|
• inflammatory lesions in many organs, including the nasal mucosa, stomach, pancreas, colon and small intestine
|
hematopoietic system
• neutrophils show impaired chemotaxis to TGF-beta
|
• symptomatic mutants show a reduction in the cellularity of the thymus
|
• symptomatic mutants have an involuted thymus
|
• commonly see extramedullary hematopoiesis within the liver and spleen
|
• absolute increase in white blood cell counts
|
• increased numbers of circulating neutrophils
|
• increased numbers of circulating monocytes
|
small spleen
(
J:53510
)
• symptomatic mutants have a small spleen
|
• symptomatic mutants show a reduction in the cellularity of the spleen
|
• T cells invade normal regions of B cell development and germinal center formation in lymph nodes
|
• lymph node T cells from enlarged submandibular and mesenteric lymph nodes exhibit an activated phenotype with an increased number of CD62L cells
|
digestive/alimentary system
• rare (1 in 13 mice) development of colonic adenocardinomas in mice >6 months
|
endocrine/exocrine glands
• symptomatic mutants show a reduction in the cellularity of the thymus
|
• symptomatic mutants have an involuted thymus
|
skeleton
neoplasm
• rare (1 in 13 mice) development of colonic adenocardinomas in mice >6 months
|
cellular
• neutrophils show impaired chemotaxis to TGF-beta
|