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Phenotypes Associated with This Genotype
Genotype
MGI:2181785
Allelic
Composition
Lhx2tm1Dra/Lhx2tm1Dra
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1Dra mutation (0 available); any Lhx2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die by E15.5 due to severe anemia
• some mutant pups are stillborn; these are pale and hydropic

growth/size/body
• at E13.5, homozygotes display a flattened forehead due to cerebral cortex anomalies

homeostasis/metabolism
• mutant embryos are hydropic

integument
• at >E13.5, mutant embryos are significantly paler than wild-type embryos

vision/eye
• no lens is observed by E13.5
• eye development arrests after formation of the optic vesicle but prior to the formation of the optic cup
• at E9.5, the ectoderm fails to thicken and form a lens placode
• however, in some mutant embryos, eyelid folds and extraocular muscles persist after E13.5
• no lens placode is observed at E9.5
• formation of the optic vesicle is arrested at E9.5
• only a small remnant of the optic vesicle is noted by E10.5
• no retina is observed by E13.5
• at E13.5, homozygotes are anophthalmic; the eye proper (globus) is absent

nervous system
• at >E12.5, homozygotes display a significant size reduction of the forebrain
• at E12.5, homozygotes display hypoplasia of the basal ganglia
• at E12.5, homozygotes display hypoplasia of the cortical plate
• at E12.5, homozygotes display agenesis of the hippocampus anlagen (aplasia of the archicortex)
• at E12.5, homozygotes display hypoplasia of the cerebral cortex due to a defect in precursor cell proliferation, as revealed by BrdU staining
• at E12.5, homozygotes display hypoplasia of the neocortex due to a proliferative defect
• homozygotes lack a well developed olfactory bulb due to gross brain malformation

hematopoietic system
• homozygotes exhibit inefficient definitive erythropoeisis due to a defective extracellular fetal liver microenvironment
• at E13.5, homozygotes show a 7-fold reduction in the absolute number of nucleated cells present in liver relative to control mice
• by E15.5, most of the erythrocytes in mutant embryos are of the mature type; however, their number is significantly decreased, as reflected by the reduction of hematocrit levels
• a severe anemia is observed between E13.5 and E15.5
• at E13.5, the total numbers, per mutant liver, of BFU- and CFU-erythroid progenitors are decreased 16-fold and 40-fold, respectively
• in contrast, the number of CFU-granulocyte/macrophage progenitors is reduced by 8%, in proportion to the reduction noted in total liver cellularity
• a significant reduction of hematocrit levels is observed between E13.5 and E15.5
• by E15, hematocrit levels are reduced to 10% of control levels

liver/biliary system
• at E13.5, the liver is smaller than normal
• at E13.5, homozygotes show a 7-fold reduction in total liver cellularity relative to wild-type embryos

craniofacial
• at E13.5, homozygotes display a flattened forehead due to cerebral cortex anomalies


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory