Phenotypes Associated with This Genotype

Genotype
MGI:2181585

• Allelic Composition: Kif3a^tm1Gsn/Kif3a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Kif3a^tm1Gsn/Kif3a^tm1Gsn embryos display morphological and asymmetrical defects

embryo

abnormal embryo turning ( J:54575 )

• at E9.5, a subset (4 of 34) heterozygotes fail to undergo turning from lordotic to fetal position

decreased embryo size ( J:54575 )

• after E9.0, a subset (4 of 34) heterozygotes appear smaller than all wild-type embryos and most heterozygous (30/34) littermates

cardiovascular system

abnormal heart looping ( J:54575 )

• at E9.5, a subset (4 of 34) heterozygotes display retarded but normal cardiac looping along with pericardial edema

pericardial edema ( J:54575 )

• at E9.5, a subset (4 of 34) heterozygotes display pericardial edema

growth/size/body

decreased embryo size ( J:54575 )

• after E9.0, a subset (4 of 34) heterozygotes appear smaller than all wild-type embryos and most heterozygous (30/34) littermates

homeostasis/metabolism

pericardial edema ( J:54575 )

• at E9.5, a subset (4 of 34) heterozygotes display pericardial edema