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Phenotypes Associated with This Genotype
Genotype
MGI:2179823
Allelic
Composition
Il2rgtm1Cgn/Y
Genetic
Background
involves: 129 * CB20
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Cgn mutation (1 available); any Il2rg mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 22-fold reduction in cellularity (J:22521)
• 22-fold reduction in cellularity (J:22521)
• 10-fold less cellularity of thymus from fetal day E15.5 through birth (J:111821)
• 20-fold less cellularity by six days of age (J:111821)
• 10-fold less cellularity of thymus from fetal day E15.5 through birth (J:111821)
• 20-fold less cellularity by six days of age (J:111821)
• thymocytes do not activate in response to Con A (J:22521)
• thymocytes do not activate in response to Con A (J:22521)
• in vitro class switch using LPS and IL-4 fail to generate more IgG1-positive cells (J:22521)
• in vitro class switch using LPS and IL-4 fail to generate more IgG1-positive cells (J:22521)
• complete absence of gamma-delta T cells in adult thymus (J:111821)
• few gamma-delta T cells found in fetal thymus (J:111821)
• TCR-gamma rearrangements are severely reduced (J:111821)
• complete absence of gamma-delta T cells in adult thymus (J:111821)
• few gamma-delta T cells found in fetal thymus (J:111821)
• TCR-gamma rearrangements are severely reduced (J:111821)
• 12-fold reduction in the spleen in 3-4 week old mice (J:22521)
• further loss occurs with age (J:22521)
• 12-fold reduction in the spleen in 3-4 week old mice (J:22521)
• further loss occurs with age (J:22521)
• plasma cells in the gut are exceptionally rare (J:22521)
• plasma cells in the gut are exceptionally rare (J:22521)
• 20-fold decrease in bone marrow though some cells are still present (J:22521)
• 20-fold decrease in bone marrow though some cells are still present (J:22521)
• NK cells are not detected in the spleen (J:22521)
• NK cells are not detected in the spleen (J:22521)
• 3 fold reduction of mature alphabeta T cells in the spleen (J:22521)
• reduction of T cells in lamina propia of gut is observed (J:22521)
• 3 fold reduction of mature alphabeta T cells in the spleen (J:22521)
• reduction of T cells in lamina propia of gut is observed (J:22521)
• no gamma-delta T cells are found in peripheral lymphnoid organs or skin (J:111821)
• no gamma-delta T cells are found in peripheral lymphnoid organs or skin (J:111821)
• 12-fold reduction in number of T cells found in gut epithelium (J:22521)
• 12-fold reduction in number of T cells found in gut epithelium (J:22521)
• 8-fold reduction in cellularity (J:22521)
• 8-fold reduction in cellularity (J:22521)
• no germinal centers are observed (J:22521)
• no germinal centers are observed (J:22521)
• clusters of white pulp are diminished in number and size (J:22521)
• clusters of white pulp are diminished in number and size (J:22521)
• no IgE detected in the sera (J:22521)
• no IgE detected in the sera (J:22521)
• 3-fold reduction in sera levels (J:22521)
• 3-fold reduction in sera levels (J:22521)
• no splenic NK killing activity is observed against a NK-sensitive target cell line (J:22521)
• no splenic NK killing activity is observed against a NK-sensitive target cell line (J:22521)
• splenic T cells do not proliferate in response to Con A (J:22521)
• splenic T cells do not proliferate in response to Con A (J:22521)
• Peyer's patchers are not observed (J:22521)
• Peyer's patchers are not observed (J:22521)

hematopoietic system
• 22-fold reduction in cellularity (J:22521)
• 22-fold reduction in cellularity (J:22521)
• 10-fold less cellularity of thymus from fetal day E15.5 through birth (J:111821)
• 20-fold less cellularity by six days of age (J:111821)
• 10-fold less cellularity of thymus from fetal day E15.5 through birth (J:111821)
• 20-fold less cellularity by six days of age (J:111821)
• thymocytes do not activate in response to Con A (J:22521)
• thymocytes do not activate in response to Con A (J:22521)
• in vitro class switch using LPS and IL-4 fail to generate more IgG1-positive cells (J:22521)
• in vitro class switch using LPS and IL-4 fail to generate more IgG1-positive cells (J:22521)
• complete absence of gamma-delta T cells in adult thymus (J:111821)
• few gamma-delta T cells found in fetal thymus (J:111821)
• TCR-gamma rearrangements are severely reduced (J:111821)
• TCR-gamma rearrangements are severely reduced (J:111821)
• complete absence of gamma-delta T cells in adult thymus (J:111821)
• few gamma-delta T cells found in fetal thymus (J:111821)
• 12-fold reduction in the spleen in 3-4 week old mice (J:22521)
• further loss occurs with age (J:22521)
• 12-fold reduction in the spleen in 3-4 week old mice (J:22521)
• further loss occurs with age (J:22521)
• plasma cells in the gut are exceptionally rare (J:22521)
• plasma cells in the gut are exceptionally rare (J:22521)
• 20-fold decrease in bone marrow though some cells are still present (J:22521)
• 20-fold decrease in bone marrow though some cells are still present (J:22521)
• NK cells are not detected in the spleen (J:22521)
• NK cells are not detected in the spleen (J:22521)
• 3 fold reduction of mature alphabeta T cells in the spleen (J:22521)
• reduction of T cells in lamina propia of gut is observed (J:22521)
• 3 fold reduction of mature alphabeta T cells in the spleen (J:22521)
• reduction of T cells in lamina propia of gut is observed (J:22521)
• no gamma-delta T cells are found in peripheral lymphnoid organs or skin (J:111821)
• no gamma-delta T cells are found in peripheral lymphnoid organs or skin (J:111821)
• 12-fold reduction in number of T cells found in gut epithelium (J:22521)
• 12-fold reduction in number of T cells found in gut epithelium (J:22521)
• 8-fold reduction in cellularity (J:22521)
• 8-fold reduction in cellularity (J:22521)
• no germinal centers are observed (J:22521)
• no germinal centers are observed (J:22521)
• clusters of white pulp are diminished in number and size (J:22521)
• clusters of white pulp are diminished in number and size (J:22521)
• no IgE detected in the sera (J:22521)
• no IgE detected in the sera (J:22521)
• 3-fold reduction in sera levels (J:22521)
• 3-fold reduction in sera levels (J:22521)
• no splenic NK killing activity is observed against a NK-sensitive target cell line (J:22521)
• no splenic NK killing activity is observed against a NK-sensitive target cell line (J:22521)
• splenic T cells do not proliferate in response to Con A (J:22521)
• splenic T cells do not proliferate in response to Con A (J:22521)

endocrine/exocrine glands
• 22-fold reduction in cellularity (J:22521)
• 22-fold reduction in cellularity (J:22521)
• 10-fold less cellularity of thymus from fetal day E15.5 through birth (J:111821)
• 20-fold less cellularity by six days of age (J:111821)
• 10-fold less cellularity of thymus from fetal day E15.5 through birth (J:111821)
• 20-fold less cellularity by six days of age (J:111821)
• thymocytes do not activate in response to Con A (J:22521)
• thymocytes do not activate in response to Con A (J:22521)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory