Mouse Genome Informatics
hm
    Il2ratm1Dw/Il2ratm1Dw
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• about 25% die between 8 and 20 weeks of age with severe anemia

hematopoietic system
• polyclonal expansion of lymphocytes beginning between 4 and 6 weeks of age
• T cells are slightly larger than in wild-type in adults, however T and B cell development is normal up to 4 weeks after birth
• increased numbers of cells bearing marker for memory cells
• develops as mice age
• develop enlargement of the spleen between 4 and 6 weeks of age
• 5- to 30-fold increase in IgA
• 5- to 30-fold increase in IgG1, IgG2a, and IgG2b
• proliferative responses to CD3 are reduced in T cells
• peripheral deletion of staphylococcal enterotoxin B (SEB)-reactive T cells is impaired

immune system
• starting at 12-16 weeks of age, develop severe bowel inflammation that is confined to the colon
• polyclonal expansion of lymphocytes beginning between 4 and 6 weeks of age
• T cells are slightly larger than in wild-type in adults, however T and B cell development is normal up to 4 weeks after birth
• increased numbers of cells bearing marker for memory cells
• 5- to 30-fold increase in IgA
• 5- to 30-fold increase in IgG1, IgG2a, and IgG2b
• proliferative responses to CD3 are reduced in T cells
• peripheral deletion of staphylococcal enterotoxin B (SEB)-reactive T cells is impaired
• develop enlargement of the spleen between 4 and 6 weeks of age
• develop enlargement of the lymph nodes between 4 and 6 weeks of age

digestive/alimentary system
• starts at 12-16 weeks of age as mice develop inflammatory bowel disease
• starting at 12-16 weeks of age, develop severe bowel inflammation that is confined to the colon

growth/size/body
• starts at 12-16 weeks of age as mice develop inflammatory bowel disease

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Interleukin 2 Receptor, Alpha, Deficiency of 606367 J:64279