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Phenotypes Associated with This Genotype
Genotype
MGI:2179512
Allelic
Composition
Il2ratm1Dw/Il2ratm1Dw
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2ratm1Dw mutation (2 available); any Il2ra mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 25% die between 8 and 20 weeks of age with severe anemia

hematopoietic system
• develops as mice age
• polyclonal expansion of lymphocytes beginning between 4 and 6 weeks of age
• T cells are slightly larger than in wild-type in adults, however T and B cell development is normal up to 4 weeks after birth
• increased numbers of cells bearing marker for memory cells
• develop enlargement of the spleen between 4 and 6 weeks of age
• 5- to 30-fold increase in IgA
• 5- to 30-fold increase in IgG1, IgG2a, and IgG2b
• proliferative responses to CD3 are reduced in T cells
• peripheral deletion of staphylococcal enterotoxin B (SEB)-reactive T cells is impaired

immune system
• starting at 12-16 weeks of age, develop severe bowel inflammation that is confined to the colon
• polyclonal expansion of lymphocytes beginning between 4 and 6 weeks of age
• T cells are slightly larger than in wild-type in adults, however T and B cell development is normal up to 4 weeks after birth
• increased numbers of cells bearing marker for memory cells
• 5- to 30-fold increase in IgA
• 5- to 30-fold increase in IgG1, IgG2a, and IgG2b
• proliferative responses to CD3 are reduced in T cells
• peripheral deletion of staphylococcal enterotoxin B (SEB)-reactive T cells is impaired
• develop enlargement of the spleen between 4 and 6 weeks of age
• develop enlargement of the lymph nodes between 4 and 6 weeks of age

digestive/alimentary system
• starts at 12-16 weeks of age as mice develop inflammatory bowel disease
• starting at 12-16 weeks of age, develop severe bowel inflammation that is confined to the colon

growth/size/body
• starts at 12-16 weeks of age as mice develop inflammatory bowel disease


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory