Phenotypes Associated with This Genotype

Genotype
MGI:2179490

• Allelic Composition: Il1r1^tm1Roml/Il1r1^tm1Roml
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased circulating interleukin-6 level ( J:42373 )

• mice have reduced circulating levels of IL-6 after turpentine injection

decreased circulating serum amyloid protein level ( J:42373 )

• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection

decreased susceptibility to type IV hypersensitivity reaction ( J:42373 )

• 50% reduction in paw swelling one day after injection in paw with methylated BSA

decreased interleukin-6 secretion ( J:42373 )

• fibroblasts fail to produce IL-6 in response to IL-1alpha or IL-1beta

increased susceptibility to bacterial infection ( J:42373 )

• 5 days after infection with Listeria monocytogenes, mice have 100- and 1000-fold greater listerial CFU in their spleens and livers, respectively, as compared with their WT littermates

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:42373 )

• mice have reduced circulating levels of IL-6 after turpentine injection

decreased circulating serum amyloid protein level ( J:42373 )

• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection

impaired febrile response ( J:42373 )

• IL-1beta injection fails to increase body temperature