Phenotypes Associated with This Genotype

Genotype
MGI:2177813

• Allelic Composition: Flt1^tm1Msh/Flt1^tm1Msh
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:49507 )

N • no abnormal cardiovascular phenotype is seen

corneal vascularization ( J:114973 )

• anti-Flt1 antibody treatment of mutant corneas induces vascularization; subconjunctival injection of anti-Flt1 antibodies also elicits corneal vascularization, but not in wild-type corneas

• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

reproductive system

reproductive system phenotype ( J:49507 )

N • no abnormal reproductive phenotype is seen

vision/eye

corneal vascularization ( J:114973 )

• anti-Flt1 antibody treatment of mutant corneas induces vascularization; subconjunctival injection of anti-Flt1 antibodies also elicits corneal vascularization, but not in wild-type corneas

• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

immune system

impaired macrophage chemotaxis ( J:49507 )

• VEGF-induced macrophage migration is almost completely abrogated

cellular

impaired macrophage chemotaxis ( J:49507 )

• VEGF-induced macrophage migration is almost completely abrogated

hematopoietic system

impaired macrophage chemotaxis ( J:49507 )

• VEGF-induced macrophage migration is almost completely abrogated