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Phenotypes Associated with This Genotype
Genotype
MGI:2177545
Allelic
Composition
Cftrtm2Hgu/Cftrtm2Hgu
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm2Hgu mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• focal hypertrophy of goblet cells, however do not observe distension of crypts in the small intestine or intestinal blockage
• defect in chloride ion transport in the jejunum but not the caecum

respiratory system
• defect in chloride ion transport in the nose, with baseline nasal biolelectrics significantly raised and a reduced response to a low chloride gradient

craniofacial
N
• teeth are normal in color

reproductive system
N
• males and females are fertile

Mouse Models of Human Disease
OMIM ID Ref(s)
Cystic Fibrosis; CF 219700 J:74740


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory