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Phenotypes Associated with This Genotype
Genotype
MGI:2177312
Allelic
Composition
Tmc1dn/Tmc1dn
Genetic
Background
STOCK Grhl3ct/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1dn mutation (3 available); any Tmc1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• degeneration of most elements of the scala media complex is underway by three weeks of age (J:236)
• degeneration of most elements of the scala media complex is underway by three weeks of age (J:236)
• Dieters cell boundaries become indistinct and nuclei move to different levels by 10 days of age (J:236)
• Dieters cell boundaries become indistinct and nuclei move to different levels by 10 days of age (J:236)
• by 9 months of age, the organ is a mass of undifferentiated cells, although the tunnel of Corti does not usually collapse (J:236)
• by 9 months of age, the organ is a mass of undifferentiated cells, although the tunnel of Corti does not usually collapse (J:236)
• abnormalities can be detected at 10 days of age (J:236)
• abnormalities can be detected at 10 days of age (J:236)
• the free end of the membrane curls up rather than resting on hair cells by 10 days (J:236)
• the free end of the membrane curls up rather than resting on hair cells by 10 days (J:236)
• some degeneration is observed in most mice (J:236)
• in severe cases, hair cells degenerate completely (J:236)
• some degeneration is observed in most mice (J:236)
• in severe cases, hair cells degenerate completely (J:236)
• in some mice, the otolith membrane degenerates completely and otoliths are lost (J:236)
• in some mice, the otolith membrane degenerates completely and otoliths are lost (J:236)
• mice do not respond to clicking (J:236)
• mice do not respond to clicking (J:236)

behavior/neurological
• tossing movement is observed in some mice although behavior is otherwise normal (J:236)
• tossing movement is observed in some mice although behavior is otherwise normal (J:236)

nervous system
N
• no abnormal central or peripheral nervous system phenotupes detected (J:6806)
• no abnormal central or peripheral nervous system phenotupes detected (J:6806)
• spiral ganglion degeneration begins at 50 days of age (J:236)
• by 9 months, degeneration is nearly complete (J:236)
• spiral ganglion degeneration begins at 50 days of age (J:236)
• by 9 months, degeneration is nearly complete (J:236)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory