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Phenotypes Associated with This Genotype
Genotype
MGI:2177295
Allelic
Composition
Amelxtm1Kul/Amelxtm1Kul
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amelxtm1Kul mutation (1 available); any Amelx mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Enamel hypoplasia in Amelxtm1Kul/Amelxtm1Kul incisors

skeleton
• teeth show a chalky-white discoloration as early as 2 weeks of age
• absence of prism pattern of organized mineral crystals in enamel
• mandibular molars show an enamel thickness with less than 10% of normal enamel
• tips of incisors and molars are broken

craniofacial
• teeth show a chalky-white discoloration as early as 2 weeks of age
• absence of prism pattern of organized mineral crystals in enamel
• mandibular molars show an enamel thickness with less than 10% of normal enamel
• tips of incisors and molars are broken

growth/size/body
• teeth show a chalky-white discoloration as early as 2 weeks of age
• absence of prism pattern of organized mineral crystals in enamel
• mandibular molars show an enamel thickness with less than 10% of normal enamel
• tips of incisors and molars are broken

Mouse Models of Human Disease
OMIM ID Ref(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:71126


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory