Phenotypes Associated with This Genotype

Genotype
MGI:2176928

• Allelic Composition: Gfra1^tm1Rosl/Gfra1^tm1Rosl
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:68750 )

• homozygotes die between 1 and 1.5 days after birth

behavior/neurological

behavior/neurological phenotype ( J:68750 )

N • initially able to suckle

N • initially show normal limb and body movements

nervous system

abnormal enteric neuron morphology ( J:68750 )

• very few enteric neurons in the stomach

absent enteric neurons ( J:68750 )

• enteric neurons belonging to myenteric and submucosal plexi of the intestine and colon are absent

loss of dopaminergic neurons ( J:68750 )

• fail to survive in the presence of GDNF although parasympathetic and submandibular neurons will survive

abnormal somatic nervous system morphology ( J:68750 )

small petrosal ganglion ( J:68750 )

• 15% loss of petrosal-nodose sensory ganglion neurons

abnormal nodose ganglion morphology ( J:68750 )

• neurons fail to survive in the presence of GDNF

abnormal trigeminal nerve morphology ( J:68750 )

• loss of about 22% of trigeminal motor neurons

abnormal spinal nerve morphology ( J:68750 )

• loss of about 24% of lumbar spinal neurons

renal/urinary system

abnormal kidney morphology ( J:68750 )

• bilateral kidney and uretal deficiency

absent nephron ( J:68750 )

• no nephrons

absent ureter ( J:68750 )

absent ureteric bud ( J:68750 )

• fails to form

immune system

decreased Peyer's patch number ( J:120816 )

• fewer patches but patches are well formed

embryo

abnormal Wolffian duct morphology ( J:68750 )

• mesonephric duct is present at E12.5 but derivative structures do not form