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Phenotypes Associated with This Genotype
Genotype
MGI:2176892
Allelic
Composition
Dmdmdx/Y
Dtnatm1Jrs/Dtnatm1Jrs
Genetic
Background
involves: 129X1/SvJ * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (42 available); any Dmd mutation (159 available)
Dtnatm1Jrs mutation (1 available); any Dtna mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• life span is 8-10 months

muscle
• develop moderate to severe cardiomyopathy
• exhibit a more severe dystrophy than single Dmdmdx mutant mice, but not as severe as that of double mutant Utrntm1Jrs and Dmd mdx mice or triple mutant Utrntm1Jrs, Dtnatm1Jrs, and Dmdmdx mice

cardiovascular system
• develop moderate to severe cardiomyopathy

nervous system
• at 2-4 months of age, synapses are broken into discrete boutons and acetylcholine receptors are patchily distributed within the boutons

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:59675


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory