Mouse Genome Informatics
hm
    Nf1tm1Cbr/Nf1tm1Cbr
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• mice exhibit impaired contextual discrimination; during first two days of training, mutants do not discriminate between a chamber in which they receive a mild shock and a chamber in which they do not, however after 3 days of training, begin to discriminate between the chambers
• in a probe trial, mutants search randomly rather than selectively, and spend significantly less time searching for the platform in the training quadrant than wild-type
• additional training alleviates the learning deficits
• mice fall off a rotating rod sooner than wild-type, however swimming speed, ambulance, exploratory behavior, and muscular strength are normal

tumorigenesis
N
• mice do not have an increase in predisposition for tumor formation (J:68489)

nervous system
N
• mice do not exhibit gross or microscopic abnormalities in the brain, including no astrogliosis (J:68489)

Mouse Models of Human Disease
OMIM IDRef(s)
Neurofibromatosis, Type I; NF1 162200 J:68489