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Phenotypes Associated with This Genotype
Genotype
MGI:2176762
Allelic
Composition
Nf1tm1Cbr/Nf1tm1Cbr
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Cbr mutation (1 available); any Nf1 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impaired contextual discrimination; during first two days of training, mutants do not discriminate between a chamber in which they receive a mild shock and a chamber in which they do not, however after 3 days of training, begin to discriminate between the chambers
• in a probe trial, mutants search randomly rather than selectively, and spend significantly less time searching for the platform in the training quadrant than wild-type
• additional training alleviates the learning deficits
• mice fall off a rotating rod sooner than wild-type, however swimming speed, ambulance, exploratory behavior, and muscular strength are normal

neoplasm
N
• mice do not have an increase in predisposition for tumor formation

nervous system
N
• mice do not exhibit gross or microscopic abnormalities in the brain, including no astrogliosis

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:68489


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory