Phenotypes Associated with This Genotype

Genotype
MGI:2176737

• Allelic Composition: Bcl2l2^tm1Sco/Bcl2l2^tm1Sco
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased male germ cell apoptosis ( J:50338 )

♂ • at 8 weeks of age the number of apoptotic male germ cells was 5 times the normal level, resulting in the testes losing 70% of their mass due to germ cell loss

abnormal reproductive system morphology ( J:50338 )

♂

azoospermia ( J:50338 )

♂ • cauda epididymides of mutant mice are devoid of sperm

multinucleated giant male germ cells ( J:50338 )

♂

abnormal seminiferous tubule epithelium morphology ( J:50338 )

♂ • numerous degenerating cells are present, some in the form of symplasts, giant cells containing multiple degenerating nuclei

decreased Sertoli cell number ( J:50338 )

♂ • Sertoli cell numbers are reduced to 16% of their normal level at 6 weeks of age

small seminiferous tubules ( J:50338 )

♂ • small in diameter and often lack a lumen

male infertility ( J:50338 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:50338 )

♂ • numerous degenerating cells are present, some in the form of symplasts, giant cells containing multiple degenerating nuclei

decreased Sertoli cell number ( J:50338 )

♂ • Sertoli cell numbers are reduced to 16% of their normal level at 6 weeks of age

small seminiferous tubules ( J:50338 )

♂ • small in diameter and often lack a lumen

cellular

azoospermia ( J:50338 )

♂ • cauda epididymides of mutant mice are devoid of sperm

multinucleated giant male germ cells ( J:50338 )

♂

increased male germ cell apoptosis ( J:50338 )

♂ • at 8 weeks of age the number of apoptotic male germ cells was 5 times the normal level, resulting in the testes losing 70% of their mass due to germ cell loss