Phenotypes Associated with This Genotype

Genotype
MGI:2176568

• Allelic Composition: Egfr^wa2/Egfr^wa2
• Genetic Background: STOCK Egfr^wa2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aortic valve morphology ( J:60750 )

• aortic valve size ranges from unaffected to mildly or markedly thickened

enlarged semilunar valve ( J:60750 )

• about 80% exhibit semilunar valve enlargement

aortic valve regurgitation ( J:60750 )

• valve abnormalities persist into adulthood causing moderate to severe regurgitation

increased left ventricle systolic pressure ( J:60750 )

• higher peak left ventricular systolic pressure and a trend towards increased +dP/dT

prolonged RR interval ( J:60750 )

prolonged PR interval ( J:60750 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
aortic valve disease		DOID:62		J:60750