Mouse Genome Informatics
either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * MF1)
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• die between E8.5 and E10.5

• epiblast contains numerous pyknotic nuclei
• egg cylinders are smaller and stubby at E7.5
• despite the formation of the three germ layers, embryos do not expand normally, are disorganized, and exhibit dense, amorphous masses of cells in some areas
• at E8.5, the amniotic cavity often contains dead cells with pyknotic nuclei
• at E8.5, the amniotic cavity is small
• thicker Reichert's membrane that exhibits many interspersed nodules covered with clusters of parietal cells
• extraembryonic portion of the E7.5 embryo appears folded and disorganized
• the surface of the visceral endoderm consists of semi-spherical blebs due to numerous invaginations
• at E8.5, embryos appear underdeveloped and have not progressed beyond the E7.5 egg cylinder stage, however E6.5 embryos are indistinguishable from wild-type

• E7.5 embryos exhibit an increase in apoptotic cells
• epiblast contains numerous pyknotic nuclei

Mouse Models of Human Disease
NOT Huntington Disease; HD 143100 J:29267