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Phenotypes Associated with This Genotype
Genotype
MGI:2176436
Allelic
Composition
Htttm1Szi/Htttm1Szi
Genetic
Background
either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * MF1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm1Szi mutation (0 available); any Htt mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between E8.5 and E10.5

embryo
• E7.5 embryos exhibit an increase in apoptotic cells
• epiblast contains numerous pyknotic nuclei
• at E8.5, embryos appear underdeveloped and have not progressed beyond the E7.5 egg cylinder stage, however E6.5 embryos are indistinguishable from wild-type
• egg cylinders are smaller and stubby at E7.5
• despite the formation of the three germ layers, embryos do not expand normally, are disorganized, and exhibit dense, amorphous masses of cells in some areas
• at E8.5, the amniotic cavity often contains dead cells with pyknotic nuclei
• at E8.5, the amniotic cavity is small
• thicker Reichert's membrane that exhibits many interspersed nodules covered with clusters of parietal cells
• extraembryonic portion of the E7.5 embryo appears folded and disorganized
• the surface of the visceral endoderm consists of semi-spherical blebs due to numerous invaginations

cellular
• E7.5 embryos exhibit an increase in apoptotic cells
• epiblast contains numerous pyknotic nuclei

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Huntington Disease; HD 143100 J:29267


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory