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Phenotypes Associated with This Genotype
Genotype
MGI:2175881
Allelic
Composition
Fbxw4Dac/Fbxw4+
mdac/mdac
Genetic
Background
involves: SM/Ckc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw4Dac mutation (1 available); any Fbxw4 mutation (28 available)
mdac mutation (0 available); any Mdac mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• particularly the three middle digits, on each foot
• often the metatarsal and metacarpal bones are partially or completely missing or fused; the forefeet are more severely affected than the hindfeet
• the defects are clearly recognizable in 15-day embryos

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
split hand-foot malformation 3 DOID:0090025 OMIM:246560
J:29220 , J:133888


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory