Mouse Genome Informatics
ot
    Dmdmdx/Y
C57BL/10ScSnJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• muscular tremors noticeable by 12 months of age (J:7361)
• mild incoordination noticeable by 12 months of age (J:7361)

muscle
• development of electron-dense bodies in the mitochondria resulting in swelling and degenerating mitochondria, and disruption of the plasmalemma basal lamina (J:7361)
• the normal myofibrillar architecture of bands and lines disappears and myofilaments disintegrate and become misaligned (J:7361)
• variable muscle fiber size; progressive starting at 3 weeks of age (J:7361)
• exhibit mild muscle fibrosis, however there is no replacement of lost muscle by fat cells (J:7361)
• progressive starting at 9 weeks of age (J:7361)
• progressive starting at 3 weeks of age (J:7361)
• progressive starting at 3 weeks of age (J:7361)
• increased intracellular sodium concentration in muscle; increased severity with age (J:3666)
• progressive degenerative myopathy; increased severity with age (J:7361)

homeostasis/metabolism
• exhibit elevated blood levels of creatine kinase (J:7361)
• exhibit elevated blood levels of pyruvate kinase (J:7361)

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:7361