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Phenotypes Associated with This Genotype
Genotype
MGI:2175799
Allelic
Composition
Cryaatm1Wawr/Cryaatm1Wawr
Genetic
Background
involves: 129/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaatm1Wawr mutation (0 available); any Cryaa mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lens opacity in Cryaatm1Wawr/Cryaatm1Wawr mice

vision/eye
• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis
• mild cataract at 7 weeks of age; progressive severity to dense opacity by 10 weeks of age
• small lens; 25-35% reduced weight and 15% reduced axial and equatorial dimensions
• inclusion bodies composed of crystallin proteins observed in nuclear and inner cortical regions
• small eyes

cellular
• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 9 multiple types DOID:0110266 OMIM:604219
J:38210


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory