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Phenotypes Associated with This Genotype
Genotype
MGI:2175797
Allelic
Composition
Crkltm1Imo/Crkltm1Imo
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkltm1Imo mutation (0 available); any Crkl mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than 2% of homozygous mutants survive to birth; E16.5 was the last day homozygous mutant embryos were successfully recovered in utero

cardiovascular system
• cervical emergence of the right subclavian artery in 40% of mutant mice
• left atrium is small and white in some E16.5 embryos
• right atrium is enlarged and engorged with blood in some E16.5 embryos
• all exhibit a ventricular septal defect

craniofacial
• E16.5 embryos exhibit mild cranial skeleton defects and about 12% of homozygotes show severe craniofacial abnormalities
• anterior-posterior expansion of the frontal bone is limited in 50% of embryos
• nasal bones exhibit poor membranous ossification at the posterior edge at E16.5
• anterior-posterior expansion of the nasal bones is limited in 50% of embryos

endocrine/exocrine glands
• 40% have abnormalities in the development of the parathyroid gland; defects include an ectopic or unilaterally absent parathyroid gland, or a parathyroid gland fused to an ectopic thymus
• 40% have abnormalities in the development of the thymus; thymus is hypoplastic, malpositioned, malformed (fused lobes) or completely missing at E16.5
• 40% have abnormalities in the development of the thyroid gland

hearing/vestibular/ear

immune system
• 40% have abnormalities in the development of the thymus; thymus is hypoplastic, malpositioned, malformed (fused lobes) or completely missing at E16.5

vision/eye

nervous system
• defects in neural crest-derived portions of the IXth nerves at E10.5
• glial cells are either absent or greatly reduced in the proximal region of nerve IX
• defects in neural crest-derived portions of the Vth nerves at E10.5
• subset of embryos show a reduced size or misshapen ophthalmic lobe of the Vth ganglion
• defects in neural crest-derived portions of the Xth nerves at E10.5
• glial cells are either absent or greatly reduced in the proximal region of nerve X

growth/size/body
• surviving mice weigh about 10-20% less than wild-type

skeleton
• anterior-posterior expansion of the frontal bone is limited in 50% of embryos
• nasal bones exhibit poor membranous ossification at the posterior edge at E16.5
• anterior-posterior expansion of the nasal bones is limited in 50% of embryos

hematopoietic system
• 40% have abnormalities in the development of the thymus; thymus is hypoplastic, malpositioned, malformed (fused lobes) or completely missing at E16.5

integument
• 40% of homozygotes between E12.5 and E16.5 appear extremely pale


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory