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Phenotypes Associated with This Genotype
Genotype
MGI:2175794
Allelic
Composition
Crebbptm1Dli/Crebbp+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Dli mutation (1 available); any Crebbp mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

craniofacial
• craniofacial abnormalities (J:60630)
• craniofacial abnormalities (J:60630)

tumorigenesis
• hematologic neoplasia in animals 1 year or older, which include histiocytic sarcomas, a tumor of hematopoietic origin, and myelogenous and lymphocytic leukemias (J:60630)
• hematologic neoplasia in animals 1 year or older, which include histiocytic sarcomas, a tumor of hematopoietic origin, and myelogenous and lymphocytic leukemias (J:60630)
• myelogenous and lymphocytic leukemias (J:60630)
• myelogenous and lymphocytic leukemias (J:60630)

hematopoietic system
• abundance of all hematopoietic cells types is significantly diminished in mice with splenomegaly (J:60630)
• increase in myeloid cells in mice with splenomegaly (J:60630)
• abundance of all hematopoietic cells types is significantly diminished in mice with splenomegaly (J:60630)
• increase in myeloid cells in mice with splenomegaly (J:60630)
• 2 of 14 mice at 3-4 months of age have small clusters of immature cells in the center of the marrow space, indicative of very early stages of myelodysplastic hematopoiesis (J:191503)
• 2 of 14 mice at 3-4 months of age have small clusters of immature cells in the center of the marrow space, indicative of very early stages of myelodysplastic hematopoiesis (J:191503)
• mutants show an increase in Annexin V+ cells in the lineage-depleted (Lin-) fraction of the marrow enriched for stem and progenitor cells, indicating an increase in apoptosis in marrow progenitors (J:191503)
• mutants show an increase in Annexin V+ cells in the lineage-depleted (Lin-) fraction of the marrow enriched for stem and progenitor cells, indicating an increase in apoptosis in marrow progenitors (J:191503)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• mutants have fewer total colony-forming cells in the marrow than wild-type mice, most notably the granulocytic and monocytic colony-forming cells (J:191503)
• 9-12 month old mutants show a decrease in common myeloid progenitors (J:191503)
• mutants have fewer total colony-forming cells in the marrow than wild-type mice, most notably the granulocytic and monocytic colony-forming cells (J:191503)
• 9-12 month old mutants show a decrease in common myeloid progenitors (J:191503)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• bone marrow is more cellular than in wild type mice when corrected for body weight at 3-4 and 9-12 months of age (J:191503)
• bone marrow is more cellular than in wild type mice when corrected for body weight at 3-4 and 9-12 months of age (J:191503)
• more than 50% of 9-12 month old mutants exhibit either increased numbers of megakaryocytes or abnormal forms such as hyperlobulated cells or naked nuclei (J:191503)
• more than 50% of 9-12 month old mutants exhibit either increased numbers of megakaryocytes or abnormal forms such as hyperlobulated cells or naked nuclei (J:191503)
• approximate 2-fold fewer long-term hematopoietic stem cells per femur at 9-12 months of age (J:191503)
• approximate 2-fold fewer long-term hematopoietic stem cells per femur at 9-12 months of age (J:191503)
• 22% of 9-12 month old mutants show leukocytes with a pseudo Pelger-Huet anomaly (J:191503)
• 22% of 9-12 month old mutants show leukocytes with a pseudo Pelger-Huet anomaly (J:191503)
• 55% of 9-12 month old mutants show hypersegemented granulocytes (J:191503)
• 55% of 9-12 month old mutants show hypersegemented granulocytes (J:191503)
• at 9-12 months of age (J:191503)
• at 9-12 months of age (J:191503)
• lymphoid cell compartment is smaller at 9-12 months of age (J:191503)
• however, leukocyte, erythrocyte and platelet numbers are normal (J:191503)
• lymphoid cell compartment is smaller at 9-12 months of age (J:191503)
• however, leukocyte, erythrocyte and platelet numbers are normal (J:191503)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• severe splenomegaly in 73% of 12-18 month old mice but not in young mice (J:60630)
• spleen contains an excess of myeloid and erythroid cells (J:60630)
• severe splenomegaly in 73% of 12-18 month old mice but not in young mice (J:60630)
• spleen contains an excess of myeloid and erythroid cells (J:60630)
• mild but significant splenomegaly in 3-4 and 9-12 month old mutants (J:191503)
• mild but significant splenomegaly in 3-4 and 9-12 month old mutants (J:191503)

immune system
• 22% of 9-12 month old mutants show leukocytes with a pseudo Pelger-Huet anomaly (J:191503)
• 22% of 9-12 month old mutants show leukocytes with a pseudo Pelger-Huet anomaly (J:191503)
• 55% of 9-12 month old mutants show hypersegemented granulocytes (J:191503)
• 55% of 9-12 month old mutants show hypersegemented granulocytes (J:191503)
• at 9-12 months of age (J:191503)
• at 9-12 months of age (J:191503)
• lymphoid cell compartment is smaller at 9-12 months of age (J:191503)
• however, leukocyte, erythrocyte and platelet numbers are normal (J:191503)
• lymphoid cell compartment is smaller at 9-12 months of age (J:191503)
• however, leukocyte, erythrocyte and platelet numbers are normal (J:191503)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• in mice with splenomegaly (J:60630)
• severe splenomegaly in 73% of 12-18 month old mice but not in young mice (J:60630)
• spleen contains an excess of myeloid and erythroid cells (J:60630)
• severe splenomegaly in 73% of 12-18 month old mice but not in young mice (J:60630)
• spleen contains an excess of myeloid and erythroid cells (J:60630)
• mild but significant splenomegaly in 3-4 and 9-12 month old mutants (J:191503)
• mild but significant splenomegaly in 3-4 and 9-12 month old mutants (J:191503)

cellular
• mutants treated with a 10-Gy split-dose total body irradiation die before wild-type mice do and none survive compared to 1/3 of wild-type mice that survive, indicating increased hypersensitivity to ionizing radiation (J:191503)
• a lower percentage of mutants treated with a split-dose of 11 Gy total body irradiation followed by a bone marrow graft survive compared to wild-type mice treated in the same way (J:191503)
• mutants treated with a 10-Gy split-dose total body irradiation die before wild-type mice do and none survive compared to 1/3 of wild-type mice that survive, indicating increased hypersensitivity to ionizing radiation (J:191503)
• a lower percentage of mutants treated with a split-dose of 11 Gy total body irradiation followed by a bone marrow graft survive compared to wild-type mice treated in the same way (J:191503)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory