Phenotypes Associated with This Genotype

Genotype
MGI:2175778

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:38772 )

skeleton

abnormal rib morphology ( J:38772 )

vertebral transformation ( J:38772 )

• anterior homeotic shift of the cervical and thoracic spine such as an 8th rib attached to the sternum, or the second rib attached to the sternum at the top of the manubrium together with the first rib

thoracic vertebral transformation ( J:38772 )

• T3 shows morphological features characteristic of the immediately cranial vertebrae in the wild-type

cervical vertebral transformation ( J:38772 )

• C6 and C7 show morphological features characteristic of the immediately cranial vertebrae in the wild-type

limbs/digits/tail

short tail ( J:38772 )

• 50-60% exhibit a short or kinked tail

kinked tail ( J:38772 )

• 50-60% exhibit a short or kinked tail

neoplasm

increased intestinal adenoma incidence ( J:38772 )

• presence of multiple adenomatous polyps at 12-28 weeks of age

• tumors are found predominately in the proximal colon and occasionally in the small intestine

increased colon adenoma incidence ( J:38772 )

• tumors are found predominately in the proximal colon

• largest tumors are pedunculated tubulovillous colonic adenomata

digestive/alimentary system

increased intestinal adenoma incidence ( J:38772 )

• presence of multiple adenomatous polyps at 12-28 weeks of age

• tumors are found predominately in the proximal colon and occasionally in the small intestine

increased colon adenoma incidence ( J:38772 )

• tumors are found predominately in the proximal colon

• largest tumors are pedunculated tubulovillous colonic adenomata