Phenotypes Associated with This Genotype

Genotype
MGI:2175758

• Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:60945 )

• mice receiving serially transplanted bone marrow exhibit decreased survival compared with mice receiving similarly treated wild-type bone marrow

increased susceptibility to xenobiotic induced morbidity/mortality ( J:60945 )

• 5-fluorouracil-treated mice exhibit reduced survival compared with similarly treated wild-type mice

• when bone marrow is used to repopulate irradiated mice that are subsequently treated with 5-FU mice exhibit decreased survival compared with mice repopulated with wild-type bone marrow

digestive/alimentary system

abnormal junctional epithelium morphology ( J:102001 )

• the total area of the periodontal junctional epithelium and connective tissue islands is larger than in wild-type mice

homeostasis/metabolism

increased DNA replication ( J:59647 )

• STZ-treated mice exhibit an increase in tubular DNA synthesis compared to similarly treated wild-type mice

increased circulating cholesterol level ( J:118516 )

increased susceptibility to xenobiotic induced morbidity/mortality ( J:60945 )

• 5-fluorouracil-treated mice exhibit reduced survival compared with similarly treated wild-type mice

• when bone marrow is used to repopulate irradiated mice that are subsequently treated with 5-FU mice exhibit decreased survival compared with mice repopulated with wild-type bone marrow

decreased physiological sensitivity to xenobiotic ( J:59647 )

• streptozotocin (STZ)-treated mice fail to exhibit proteinuria, glomerular hypertrophy, and an increase in glomerular matrix unlike similarly treated wild-type mice

abnormal response to CNS ischemic injury ( J:90479 )

• 1 week after mid-cerebral artery occlusion (MCAO), proliferation of neural precursor, neural precursor cell numbers, and the number of differentiated neurons are increased compared to in similarly treated wild-type mice

• however, proliferation reverts to baseline 2 weeks after MCAO

cellular

increased sensitivity to induced cell death ( J:85569 )

• mutant MEFs are more sensitive to etoposide, adriamycin, or cisplatin induced apoptosis than wild-type MEFs

increased cellular sensitivity to ultraviolet irradiation ( J:85569 )

• MEFs are highly sensitive to UV-induced apoptosis

abnormal neuronal precursor proliferation ( J:90479 )

• 1 week after mid-cerebral artery occlusion (MCAO), proliferation of neural precursor is increased compared to in similarly treated wild-type mice

• however, proliferation reverts to baseline 2 weeks after MCAO

increased cell proliferation ( J:180692 )

• in mouse embryonic cells

increased DNA replication ( J:59647 )

• STZ-treated mice exhibit an increase in tubular DNA synthesis compared to similarly treated wild-type mice

hematopoietic system

increased hematopoietic stem cell number ( J:60945 )

• under homeostatic condition due to increased stem cell proliferation

abnormal hematopoietic stem cell physiology ( J:60945 )

• under homeostatic condition, hematopoietic stem cell proliferation is increased compared to in wild-type mice

• following repeated transplantation, self-renewal of primitive hematopoietic cells is impaired and leads to hematopoietic failure due to stem cell exhaustion unlike when wild-type bone marrow is used

• however, bone marrow cell homing is normal in serial transplantation experiments

nervous system

abnormal neuronal precursor proliferation ( J:90479 )

• 1 week after mid-cerebral artery occlusion (MCAO), proliferation of neural precursor is increased compared to in similarly treated wild-type mice

• however, proliferation reverts to baseline 2 weeks after MCAO

abnormal response to CNS ischemic injury ( J:90479 )

• 1 week after mid-cerebral artery occlusion (MCAO), proliferation of neural precursor, neural precursor cell numbers, and the number of differentiated neurons are increased compared to in similarly treated wild-type mice

• however, proliferation reverts to baseline 2 weeks after MCAO

increased brain weight ( J:118516 )

increased neuronal precursor cell number ( J:90479 )

• following mid-cerebral artery occlusion

increased neuron number ( J:90479 )

• following mid-cerebral artery occlusion

adipose tissue

increased brown adipose tissue amount ( J:118516 )

• 38% compared to in wild-type mice

increased white fat cell number ( J:118516 )

• the number of adipocytes in the parametrial fat pad is increased 1.7-fold compared to in wild-type mice

• adipocyte hyperplasia is observed in small, medium, and large adipocytes

• the number of small adipocytes is increased 1.7-fold compared to in wild-type mice

increased inguinal fat pad weight ( J:118516 )

increased parametrial fat pad weight ( J:118516 )

• 90% at 130 days compared to in wild-type mice

growth/size/body

abnormal junctional epithelium morphology ( J:102001 )

• the total area of the periodontal junctional epithelium and connective tissue islands is larger than in wild-type mice

decreased body weight ( J:102001 )

increased body weight ( J:118516 )

• at 60 to 120 days

increased kidney weight ( J:118516 )

• 18% compared to in wild-type mice

renal/urinary system

increased kidney weight ( J:118516 )

• 18% compared to in wild-type mice

craniofacial

abnormal junctional epithelium morphology ( J:102001 )

• the total area of the periodontal junctional epithelium and connective tissue islands is larger than in wild-type mice

endocrine/exocrine glands

abnormal prostate gland dorsolateral lobe morphology ( J:115443 )

♂ • prostate gland dorsolateral lobe DNA content is decreased 67% compared to in wild-type mice

decreased prostate gland dorsolateral lobe weight ( J:115443 )

♂ • prostate gland dorsolateral lobe weight is decreased 59% compared to in wild-type mice

decreased seminal vesicle weight ( J:115443 )

♂ • 27% compared to in wild-type mice

reproductive system

abnormal prostate gland dorsolateral lobe morphology ( J:115443 )

♂ • prostate gland dorsolateral lobe DNA content is decreased 67% compared to in wild-type mice

decreased prostate gland dorsolateral lobe weight ( J:115443 )

♂ • prostate gland dorsolateral lobe weight is decreased 59% compared to in wild-type mice

decreased seminal vesicle weight ( J:115443 )

♂ • 27% compared to in wild-type mice