Phenotypes Associated with This Genotype

Genotype
MGI:2175724

• Allelic Composition: Bdnf^tm1Tbn/Bdnf⁺
• Genetic Background: involves: 129S4/SvJae * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired synaptic plasticity ( J:64962 )

• frequency distributions of posttetanic synaptic enhancements indicate that in heterozygotes most potentiations are close to 100% vs >150% in wild-type mice

• after P16, heterozygotes display almost no differences in posttetanic synaptic strengthening relative to homozygotes

abnormal excitatory postsynaptic potential ( J:64962 )

• after tetanic stimulation, heterozygotes exhibit a similar reduction in mean field EPSP slopes to that observed in homozygotes

• as in homozygotes, paired pulse facilitation (ratio of second EPSP slope to first EPSP slope) is unaffected

reduced long-term potentiation ( J:64962 )

• heterozygotes display a similar reduction in LTP magnitude and % of successful LTPs in the CA1 region of the hippocampus to that observed in homozygotes

• again, the magnitude of potentiation is significantly smaller than in wild-type mice and declines slowly over time

• in contrast to homozygotes, heterozygotes are viable and display normal dorsal root ganglia and no balance or coordination deficits