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Phenotypes Associated with This Genotype
Genotype
MGI:2175713
Allelic
Composition
Avpr2tm1Jwe/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CF-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avpr2tm1Jwe mutation (0 available); any Avpr2 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pelvic space of Avpr2tm1Jwe/Y pups is enlarged in kidneys

mortality/aging
• death within the first week after birth

growth/size/body
• 3 day old pups had a 30% decrease in body weight

hematopoietic system
• increased 15-20%

homeostasis/metabolism
• blood glucose levels were 50% lower than controls
• hypernatremia, increased serum Na+
• increased serum Cl-
• 3 day old pups had a 30% reduction in urine osmolarity

renal/urinary system
• 3 day old pups had a 30% reduction in urine osmolarity
• dilated renal pelvic space

integument
• dry skin, consistent with symptoms of dehydration

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nephrogenic diabetes insipidus DOID:12387 J:66094


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory