Phenotypes Associated with This Genotype

Genotype
MGI:2175712

• Allelic Composition: Atp7a^Mo/Atp7a⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:13041 )

♀ • some survive post weaning but most die before 2 weeks of age

prenatal lethality, incomplete penetrance ( J:13041 )

♀ • partial pre-natal lethality

reproductive system

decreased litter size ( J:13041 )

♀ • litter size is about 25% smaller than in controls

pigmentation

abnormal coat/hair pigmentation ( J:249 , J:13041 )

♀ (J:249)

♀ • irregular patches of full colored and very lightly colored fur over the whole coat (J:13041)

♀ • most female heterozygotes have mottled coats, due to the Lyon effect, inactivation of one or the other of the X chromosomes; the mutant gene is active in the light patches, the wild-type gene in the dark (J:13041)

integument

abnormal coat/hair pigmentation ( J:249 , J:13041 )

♀ (J:249)

♀ • irregular patches of full colored and very lightly colored fur over the whole coat (J:13041)

♀ • most female heterozygotes have mottled coats, due to the Lyon effect, inactivation of one or the other of the X chromosomes; the mutant gene is active in the light patches, the wild-type gene in the dark (J:13041)

curly vibrissae ( J:249 )

♀ • curling of vibrissae although the hairs of the coat are not noticeably waved

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Menkes disease		DOID:1838	OMIM:309400	J:249