Analysis Tools
mortality/aging
vision/eye
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• developmental abnormalities visible as early as E9.0 and E10.5
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• no visible signs of optic cup formation at E10.5
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• optic vesicle does not form
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• no eyes at E13.5
(J:40830)
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nervous system
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• delayed anterior neural tube closure
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• reduced size of midbrain
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• the variability in this phenotype ranges from an absence of a ventral forebrain to the complete absence of a forebrain
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• severely affected embryos have no forebrain
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craniofacial
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• no optic depressions (sulci) in the neural tube at E9.0
(J:40830)
• optic pit fails to form
(J:97314)
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• absent
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cleft palate
(
J:97314
)
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• display a spectrum of craniofacial defects including severe ventral and dorsal clefts of the palate
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digestive/alimentary system
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• absent
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cleft palate
(
J:97314
)
|
• display a spectrum of craniofacial defects including severe ventral and dorsal clefts of the palate
|
embryo
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• delayed anterior neural tube closure
|
cellular
growth/size/body
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• absent
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cleft palate
(
J:97314
)
|
• display a spectrum of craniofacial defects including severe ventral and dorsal clefts of the palate
|
