Phenotypes Associated with This Genotype

Genotype
MGI:2175193

• Allelic Composition: Nuca/Nuca⁺
• Genetic Background: involves: 101 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased litter size ( J:6686 , J:9528 )

• rare fertile heterozygotes exhibit a greatly reduced litter size with considerable prenatal mortality (J:6686)

infertility ( J:6686 )

• most heterozygotes are sterile

• matings between heterozygotes have not produced offspring; therefore, homozygotes have not been obtained

vision/eye

cataract ( J:6686 , J:9528 )

• manifestation is bilateral and penetrance is complete (J:6686)

• central cataract (J:9528)

sutural cataract ( J:6686 , J:9528 )

• an opacity of the posterior embryonic suture is seen (J:6686)

• lens opacity of the posterior embryonic suture (J:9528)

nuclear cataract ( J:6686 , J:9528 )

• a granular opacity of the embryonic nucleus protrudes into the anterior part of the lens (J:6686)

• lens opacity of the fetal nucleus (J:9528)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:6686