Phenotypes Associated with This Genotype

Genotype
MGI:2175182

• Allelic Composition: Ntf5^tm1Jae/Ntf5^tm1Jae
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 74% and 65%, respectively, compared to in wild-type mice

decreased sensory neuron number ( J:25566 )

• significant loss of all sensory neuron types in the nodose-petrosal, geniculate and L4 dorsal root ganglion in homozygous mice

• no difference in the number of facial motor neurons or superior cervical ganglion neurons is seen compared to controls

• no difference in the number of midbrain dopaminergic neurons is seen compared to controls

small geniculate ganglion ( J:25566 )

• approximately half of the neurons are lost from the geniculate ganglion at E18.5

small petrosal ganglion ( J:25566 )

• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5

small nodose ganglion ( J:25566 )

• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5

small vestibular ganglion ( J:25566 )

• approximately 20% of the neurons are lost from the vestibular ganglion

small L4 dorsal root ganglion ( J:25566 )

• approximately 15% of the neurons are lost from the L4 DRG at two months of age

integument

abnormal hair cycle ( J:53271 )

• retarded catagen progression; follicles are still in early or middle catagen at time points when controls are in late catagen

thick skin ( J:53271 )

• skin thicker than in controls

cellular

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 74% and 65%, respectively, compared to in wild-type mice