About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2175153
Allelic
Composition
Nkx3-1tm1Mms/Nkx3-1+
Genetic
Background
either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1tm1Mms mutation (3 available); any Nkx3-1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• at 6 weeks, heterozygotes exhibit a 4.5-fold increase in epithelial cell proliferation in the anterior prostate relative to wild-type mice

endocrine/exocrine glands
• at 1 year, the anterior prostate of heterozygotes exhibits epithelial hyperplasia of reduced severity relative to homozygotes
• at 1 year, the anterior prostate of heterozygotes exhibits epithelial dysplasia of reduced severity relative to homozygotes
• in addition, heterozygous dorsolateral prostates display a mild dysplasia relative to wild-type
• adult heterozygotes exhibit progressive prostate epithelial hyperplasia of reduced severity relative to homozygotes
• adult heterozygotes show a significant reduction or loss of major secretory proteins in ventral prostate secretions

reproductive system
• at 1 year, the anterior prostate of heterozygotes exhibits epithelial hyperplasia of reduced severity relative to homozygotes
• at 1 year, the anterior prostate of heterozygotes exhibits epithelial dysplasia of reduced severity relative to homozygotes
• in addition, heterozygous dorsolateral prostates display a mild dysplasia relative to wild-type
• adult heterozygotes exhibit progressive prostate epithelial hyperplasia of reduced severity relative to homozygotes
• adult heterozygotes show a significant reduction or loss of major secretory proteins in ventral prostate secretions

neoplasm
• at 1 year, the heterozygous anterior prostate shows epithelial hyperplasia and dysplasia along with a marked increase in proliferating cells, modeling a preneoplastic condition


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory