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Phenotypes Associated with This Genotype
Genotype
MGI:2175074
Allelic
Composition
Irf8tm1Hor/Irf8tm1Hor
Genetic
Background
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8tm1Hor mutation (1 available); any Irf8 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 80% of mice infected with vacinia virus or lymphocytic choriomeningitis virus die within 10 to 20 days unlike wild-type mice that control the infection
• 33% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis

immune system
• in the bone marrow
• the relative frequency of B cells is decreased in the spleen
• the relative frequency of T cells is decreased in the spleen
• 38.9+/-9.5 leukocytes per ul x103 compared to 6.76+/-0.55 leukocytes per ul x103 in wild-type mice
• the frequency of granulocytes in the spleen, lymph node, peripheral blood and bone marrow is increased relative to in wild-type mice
• the frequency of granulocytes in the spleen and lymph nodes increases with age
• mice exhibit lymphocyte and plasma cells hyperplasia in Peyer's patches and the lamina propria
• the frequency of B cells is increased in the lymph nodes
• the relative frequency of B cells is decreased in the spleen
• the frequency of macrophage in the spleen, lymph node and bone marrow is increased relative to in wild-type mice
• the frequency of plasma cells I reduced in the bone marrow while mice exhibit plasma cells hyperplasia in Peyer's patches and the lamina propria
• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
• mice develop lymphadenopathy
• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney
• lymph nodes are enlarged 5-fold and are populated by neutrophilic granulocytes
• interferon-gamma production following stimulation with ConA is reduced 3-fold while production following stimulation with LPS is decreased more than 100-fold compared to in wild-type mice
• 80% of mice infected with vacinia virus or lymphocytic choriomeningitis virus die within 10 to 20 days unlike wild-type mice that control the infection
• cytotoxic T lymphocyte response is reduced 3- to 10-fold following infection with vesicular stomatitis virus and vacinia virus
• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney

liver/biliary system
• mice develop hepatosplenomegaly

neoplasm
• all mice develop hematologic neoplasia resembling chronic myelogenous leukemia
• 33% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis

hematopoietic system
• erythropoiesis is increased compared to in wild-type mice
• bone marrows exhibit hypercellularity due to an increase in mature granulocytes and their precursors compared to in wild-type mice
• mice exhibit increased proliferation of abnormal megakaryocytes
• in the bone marrow
• the relative frequency of B cells is decreased in the spleen
• the relative frequency of T cells is decreased in the spleen
• 38.9+/-9.5 leukocytes per ul x103 compared to 6.76+/-0.55 leukocytes per ul x103 in wild-type mice
• the frequency of granulocytes in the spleen, lymph node, peripheral blood and bone marrow is increased relative to in wild-type mice
• the frequency of granulocytes in the spleen and lymph nodes increases with age
• mice exhibit lymphocyte and plasma cells hyperplasia in Peyer's patches and the lamina propria
• the frequency of B cells is increased in the lymph nodes
• the relative frequency of B cells is decreased in the spleen
• the frequency of macrophage in the spleen, lymph node and bone marrow is increased relative to in wild-type mice
• the frequency of plasma cells I reduced in the bone marrow while mice exhibit plasma cells hyperplasia in Peyer's patches and the lamina propria
• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
• mice develop lymphadenopathy
• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial chronic myelocytic leukemia-like syndrome DOID:0060761 OMIM:600080
J:36038


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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory