Mouse Genome Informatics
hm
    Grin1tm1Bhk/Grin1tm1Bhk
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• slightly smaller than normal at birth
• weight difference persists to adulthood but the extent of the difference diminishes over time
• eventually mutants attain weights within the normal range

behavior/neurological
• increased acoustic startle response
• male response is enhanced by exposure to predator odor (soiled rat bedding)
• increased "ambulation" during habituation to a new environment
• treatment with Clozapine normalizes behavior at doses not affecting behavior of controls
• increased
• treatment with Clozapine normalizes behavior at doses not affecting behavior of controls
• all abnormal behaviors at least partially reversed by treatment with Clozapine
• no fighting by either males or females
• no aggressive mounting behavior by females unlike control females
• do not sleep in contact with littermates
• males fail to copulate with wild-type females (J:57125)
• reduced investigation of "intruder" animals
• exhibit escape behavior, avoid social interactions
• do not sleep huddled with littermates

nervous system
• deficient prepulse inhibition
• inhibition deficiency offset in males exposed to predator odor (soiled rat bedding)

reproductive system
• males fail to copulate with wild-type females (J:57125)

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:57125