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Phenotypes Associated with This Genotype
Genotype
MGI:2175046
Allelic
Composition
Grin1tm1Bhk/Grin1tm1Bhk
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Bhk mutation (0 available); any Grin1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• slightly smaller than normal at birth
• weight difference persists to adulthood but the extent of the difference diminishes over time
• eventually mutants attain weights within the normal range

behavior/neurological
• increased acoustic startle response
• male response is enhanced by exposure to predator odor (soiled rat bedding)
• increased "ambulation" during habituation to a new environment
• treatment with Clozapine normalizes behavior at doses not affecting behavior of controls
• increased
• treatment with Clozapine normalizes behavior at doses not affecting behavior of controls
• all abnormal behaviors at least partially reversed by treatment with Clozapine
• no fighting by either males or females
• no aggressive mounting behavior by females unlike control females
• do not sleep in contact with littermates
• males fail to copulate with wild-type females
• reduced investigation of "intruder" animals
• exhibit escape behavior, avoid social interactions
• do not sleep huddled with littermates

nervous system
• deficient prepulse inhibition
• inhibition deficiency offset in males exposed to predator odor (soiled rat bedding)

reproductive system
• males fail to copulate with wild-type females

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:57125


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory