About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2175031
Allelic
Composition
Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1Tbo mutation (0 available); any Foxn1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymic rudiment in the mediastinum above the heart
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked
• cortical epithelial primordia do not develop
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged
• complete absence of alpha/beta T-cells

hematopoietic system
• thymic rudiment in the mediastinum above the heart
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked
• cortical epithelial primordia do not develop
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged
• complete absence of alpha/beta T-cells

integument
• loss of expression of some but not all hair keratin genes

endocrine/exocrine glands
• thymic rudiment in the mediastinum above the heart
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked
• cortical epithelial primordia do not develop


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory