Mouse Genome Informatics
hm
    Foxn1tm1Tbo/Foxn1tm1Tbo
involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• thymic rudiment in the mediastinum above the heart
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked
• cortical epithelial primordia do not develop
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged
• complete absence of alpha/beta T-cells

hematopoietic system
• thymic rudiment in the mediastinum above the heart
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked
• cortical epithelial primordia do not develop
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged
• complete absence of alpha/beta T-cells

integument
• loss of expression of some but not all hair keratin genes

endocrine/exocrine glands
• thymic rudiment in the mediastinum above the heart
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked
• cortical epithelial primordia do not develop

Mouse Models of Human Disease
OMIM IDRef(s)
T-Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy 601705 J:33796