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Phenotypes Associated with This Genotype
Genotype
MGI:2175031
Allelic
Composition
Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1Tbo mutation (0 available); any Foxn1 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymic rudiment in the mediastinum above the heart (J:33796)
• thymic rudiment in the mediastinum above the heart (J:33796)
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked (J:177992)
• cortical epithelial primordia do not develop (J:177992)
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked (J:177992)
• cortical epithelial primordia do not develop (J:177992)
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged (J:33796)
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged (J:33796)
• complete absence of alpha/beta T-cells (J:33796)
• complete absence of alpha/beta T-cells (J:33796)

hematopoietic system
• thymic rudiment in the mediastinum above the heart (J:33796)
• thymic rudiment in the mediastinum above the heart (J:33796)
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked (J:177992)
• cortical epithelial primordia do not develop (J:177992)
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked (J:177992)
• cortical epithelial primordia do not develop (J:177992)
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged (J:33796)
• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged (J:33796)
• complete absence of alpha/beta T-cells (J:33796)
• complete absence of alpha/beta T-cells (J:33796)

integument
• loss of expression of some but not all hair keratin genes (J:61394)
• loss of expression of some but not all hair keratin genes (J:61394)

endocrine/exocrine glands
• thymic rudiment in the mediastinum above the heart (J:33796)
• thymic rudiment in the mediastinum above the heart (J:33796)
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked (J:177992)
• cortical epithelial primordia do not develop (J:177992)
• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked (J:177992)
• cortical epithelial primordia do not develop (J:177992)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory