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Phenotypes Associated with This Genotype
Genotype
MGI:2175020
Allelic
Composition
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Imx mutation (3 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation
• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered
• increased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control
• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid

homeostasis/metabolism
N
• normal recovery after superficial injury causes an increased trans-epidermal water loss
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)
• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered

nervous system
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation
• increased glutamate currents

neoplasm
• development after DMPA/TPA treatment is reduced

respiratory system
• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid

hematopoietic system
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation

integument
• development after DMPA/TPA treatment is reduced

cellular
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Hyperlipidemia, Familial Combined; FCHL 144250 J:45147
NOT Hypertension, Essential 145500 J:45147


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory