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Phenotypes Associated with This Genotype
Genotype
MGI:2175020
Allelic
Composition
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Imx mutation (3 available); any Tnfrsf1b mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation (J:112713)
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation (J:112713)
• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered (J:45147)
• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered (J:45147)
• increased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control (J:45147)
• increased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control (J:45147)
• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid (J:120174)
• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid (J:120174)

homeostasis/metabolism
N
• normal recovery after superficial injury causes an increased trans-epidermal water loss (J:59056)
• normal recovery after superficial injury causes an increased trans-epidermal water loss (J:59056)
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (J:78637)
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (J:78637)
• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered (J:45147)
• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered (J:45147)

nervous system
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (J:78637)
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (J:78637)
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation (J:112713)
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation (J:112713)
• increased glutamate currents (J:152590)
• increased glutamate currents (J:152590)

tumorigenesis
• development after DMPA/TPA treatment is reduced (J:89088)
• development after DMPA/TPA treatment is reduced (J:89088)

respiratory system
• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid (J:120174)
• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid (J:120174)

hematopoietic system
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation (J:112713)
• numbers of microglial cells significantly increased relative to controls after epileptic stimulation (J:112713)

integument
• development after DMPA/TPA treatment is reduced (J:89088)
• development after DMPA/TPA treatment is reduced (J:89088)

cellular
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (J:78637)
• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (J:78637)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Hyperlipidemia, Familial Combined; FCHL 144250 J:45147
NOT Hypertension, Essential 145500 J:45147


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory