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Phenotypes Associated with This Genotype
Genotype
MGI:2174983
Allelic
Composition
Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Dfr mutation (1 available); any Pik3r1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 5% survive beyond 7 days of age

immune system
• development impaired at the pro-B cell stage
• reduced numbers of mature B cells
• reduced proliferative responses

homeostasis/metabolism
• increased glucose tolerance in glucose tolerance tests

cardiovascular system
• calcification of cardiac tissue

liver/biliary system

muscle
• enlarged skeletal muscle fibers

adipose tissue

hematopoietic system
• development impaired at the pro-B cell stage
• reduced numbers of mature B cells
• reduced proliferative responses

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:52229 , J:65523


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory