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Phenotypes Associated with This Genotype
Genotype
MGI:2174983
Allelic
Composition
Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Dfr mutation (1 available); any Pik3r1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 5% survive beyond 7 days of age (J:52229)
• less than 5% survive beyond 7 days of age (J:52229)

immune system
• development impaired at the pro-B cell stage (J:52229)
• development impaired at the pro-B cell stage (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced proliferative responses (J:52229)
• reduced proliferative responses (J:52229)

homeostasis/metabolism
• increased glucose tolerance in glucose tolerance tests (J:65523)
• increased glucose tolerance in glucose tolerance tests (J:65523)

cardiovascular system
• calcification of cardiac tissue (J:65523)
• calcification of cardiac tissue (J:65523)

liver/biliary system

muscle
• enlarged skeletal muscle fibers (J:65523)
• enlarged skeletal muscle fibers (J:65523)

adipose tissue
• brown fat necrosis (J:65523)
• brown fat necrosis (J:65523)

hematopoietic system
• development impaired at the pro-B cell stage (J:52229)
• development impaired at the pro-B cell stage (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced proliferative responses (J:52229)
• reduced proliferative responses (J:52229)

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:52229 , J:65523


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory