Mouse Genome Informatics
hm
    Pik3r1tm1Dfr/Pik3r1tm1Dfr
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• less than 5% survive beyond 7 days of age

immune system
• reduced numbers of mature B cells
• reduced proliferative responses
• development impaired at the pro-B cell stage

homeostasis/metabolism
• increased glucose tolerance in glucose tolerance tests

cardiovascular system
• calcification of cardiac tissue

liver/biliary system

muscle
• enlarged skeletal muscle fibers

adipose tissue

hematopoietic system
• reduced numbers of mature B cells
• reduced proliferative responses
• development impaired at the pro-B cell stage

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:52229 , J:65523