Phenotypes Associated with This Genotype

Genotype
MGI:2174971

• Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk
• Genetic Background: involves: 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with Listeria monocytogenes

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with herpes simplex virus, HSV-1

immune system

increased interleukin-12 secretion ( J:110433 )

• mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with Listeria monocytogenes

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with herpes simplex virus, HSV-1