Phenotypes Associated with This Genotype

Genotype
MGI:2174963

• Allelic Composition: Irs1^tm1Jos/Irs1^tm1Jos
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased birth weight ( J:21374 )

• at birth, the body weights of homozygotes are 40-60% of those found in wild-type or heterozygous mutant littermates

decreased body size ( J:21374 )

• homozygotes are viable, fertile, and nurse successfully but grow in proportion to a smaller body size relative to wild-type mice

decreased body weight ( J:21374 )

• up to 4 months of age, the body weights of homozygotes are 50-60% of those found in wild-type littermates

postnatal growth retardation ( J:80976 )

homeostasis/metabolism

increased circulating insulin level ( J:21374 )

• in homozygotes, fasting plasma insulin levels are elevated 2.3-fold relative to wild-type levels

impaired glucose tolerance ( J:21374 )

• homozygotes have normal fasting glucose levels but exhibit a mild impairment in glucose tolerance

insulin resistance ( J:21374 )

• homozygotes exhibit a mild insulin and insulin-like growth factor-1 (IGF1) resistance

• the hypoglycemic response to insulin and IGF1 is significantly attenuated concomitant with a significant reduction in insulin-stimulated glucose transport in isolated adipocytes

skeleton

skeleton phenotype ( J:21374 )

N • homozygotes display normal ossification of long bones relative to wild-type mice

vision/eye

vision/eye phenotype ( J:98107 )

N • mice show no changes in the retina