Phenotypes Associated with This Genotype

Genotype
MGI:2174957

• Allelic Composition: Glp1r^tm1Ddr/Glp1r^tm1Ddr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:36918 , J:206563 )

• during glucose tolerance test (J:36918)

• after gavage of a standard liquid diet (J:206563)

• however, glucose levels after vertical sleeve gastrectomy are normal (J:206563)

decreased circulating insulin level ( J:36918 , J:206563 )

• during glucose tolerance test (J:36918)

• at baseline or after gavage of a standard liquid diet after vertical sleeve gastrectomy and in sham operated mice (J:206563)

impaired glucose tolerance ( J:36918 )

abnormal response to injury ( J:206563 )

• mice exhibit normal weight change rate following vertical sleeve gastrectomy

growth/size/body

decreased lean body mass ( J:206563 )

• after vertical sleeve gastrectomy and in sham operated mice

decreased body weight ( J:206563 )

• after vertical sleeve gastrectomy and in sham operated mice

• however, mice exhibit normal weight change rate following vertical sleeve gastrectomy

behavior/neurological

abnormal food intake ( J:206563 )

• after exendin-4 treatment, mice fail to exhibit a hypophagic response unlike wild-type mice

• mice exhibit unchanged protein intake after vertical sleeve gastrectomy unlike wild-type mice

decreased food intake ( J:206563 )

• 28 to 31 days after vertical sleeve gastrectomy and in sham operated mice

adipose tissue

decreased total body fat amount ( J:206563 )

• after vertical sleeve gastrectomy and in sham operated mice