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Phenotypes Associated with This Genotype
Genotype
MGI:2174947
Allelic
Composition
Edn3tm1Ywa/Edn3tm1Ywa
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn3tm1Ywa mutation (3 available); any Edn3 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice have a mean life span of 21 days, with a range of 4-65 days
• mice have a mean life span of 21 days, with a range of 4-65 days

pigmentation
• extensive white spotting (70 - 80% of body surface)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs

digestive/alimentary system
• distal portion of colon narrow and spastic; proximal portion of colon distended
• absence of myenteric ganglion neurons in distal, spastic segment of colon

nervous system
• absence of myenteric ganglion neurons in distal, spastic segment of colon

integument
• extensive white spotting (70 - 80% of body surface)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory