About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2174947
Allelic
Composition
Edn3tm1Ywa/Edn3tm1Ywa
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn3tm1Ywa mutation (2 available); any Edn3 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice have a mean life span of 21 days, with a range of 4-65 days
• mice have a mean life span of 21 days, with a range of 4-65 days

pigmentation
• extensive white spotting (70 - 80% of body surface)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs

digestive/alimentary system
• distal portion of colon narrow and spastic; proximal portion of colon distended
• absence of myenteric ganglion neurons in distal, spastic segment of colon

nervous system
• absence of myenteric ganglion neurons in distal, spastic segment of colon

integument
• extensive white spotting (70 - 80% of body surface)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory