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Phenotypes Associated with This Genotype
Genotype
MGI:2174947
Allelic
Composition
Edn3tm1Ywa/Edn3tm1Ywa
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn3tm1Ywa mutation (2 available); any Edn3 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice have a mean life span of 21 days, with a range of 4-65 days (J:22207)
• mice have a mean life span of 21 days, with a range of 4-65 days (J:22207)
• mice have a mean life span of 21 days, with a range of 4-65 days (J:22207)
• mice have a mean life span of 21 days, with a range of 4-65 days (J:22207)

pigmentation
• extensive white spotting (70 - 80% of body surface) (J:22207)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs (J:22207)
• extensive white spotting (70 - 80% of body surface) (J:22207)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs (J:22207)

digestive/alimentary system
• distal portion of colon narrow and spastic; proximal portion of colon distended (J:22207)
• distal portion of colon narrow and spastic; proximal portion of colon distended (J:22207)
• absence of myenteric ganglion neurons in distal, spastic segment of colon (J:22207)
• absence of myenteric ganglion neurons in distal, spastic segment of colon (J:22207)

nervous system
• absence of myenteric ganglion neurons in distal, spastic segment of colon (J:22207)
• absence of myenteric ganglion neurons in distal, spastic segment of colon (J:22207)

integument
• extensive white spotting (70 - 80% of body surface) (J:22207)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs (J:22207)
• extensive white spotting (70 - 80% of body surface) (J:22207)
• white regions showed absence of melanin pigment in coat hair and of melanocytes in the hair bulbs (J:22207)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory