Mouse Genome Informatics
ht
    Apoetm1Lmh/Apoe+
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning
• surface area of lesions was 6 - 30 times larger than sex-matched controls
• lesions in females larger than in males

homeostasis/metabolism
• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:22347