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Phenotypes Associated with This Genotype
Genotype
MGI:2174930
Allelic
Composition
Apoetm1Lmh/Apoe+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning (J:22347)
• surface area of lesions was 6 - 30 times larger than sex-matched controls (J:22347)
• lesions in females larger than in males (J:22347)
• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning (J:22347)
• surface area of lesions was 6 - 30 times larger than sex-matched controls (J:22347)
• lesions in females larger than in males (J:22347)

homeostasis/metabolism
• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting (J:22347)
• no increase in HDL (J:22347)
• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting (J:22347)
• no increase in HDL (J:22347)
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet (J:22347)
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet (J:22347)
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet (J:22347)
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet (J:22347)

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:22347


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory