About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2174930
Allelic
Composition
Apoetm1Lmh/Apoe+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning
• surface area of lesions was 6 - 30 times larger than sex-matched controls
• lesions in females larger than in males

homeostasis/metabolism
• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/15/2017
MGI 6.10
The Jackson Laboratory