Phenotypes Associated with This Genotype

Genotype
MGI:2174930

• Allelic Composition: Apoe^tm1Lmh/Apoe⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:22347 )

• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning

• surface area of lesions was 6 - 30 times larger than sex-matched controls

• lesions in females larger than in males

homeostasis/metabolism

abnormal lipid homeostasis ( J:22347 )

increased circulating cholesterol level ( J:22347 )

• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting

• no increase in HDL

increased circulating HDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

increased circulating VLDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet