About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2174793
Allelic
Composition
Tubtub/Tubtub
Genetic
Background
B6(Cg)-Tubtub/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubtub mutation (3 available); any Tub mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Tubtub/Tubtub

growth/size/body
• slowly develop obesity (J:32415)
• slowly develop obesity (J:32415)

behavior/neurological
• gradually increase food intake (J:32415)
• gradually increase food intake (J:32415)

homeostasis/metabolism
• gradually increase plasma insulin levels over time (J:32415)
• gradually increase plasma insulin levels over time (J:32415)
• males, but not females, show a moderate increase in cholesterol levels (J:18161)
• males, but not females, show a moderate increase in cholesterol levels (J:18161)
• elevated in both males and females, although levels are higher in males than females (J:18161)
• elevated in both males and females, although levels are higher in males than females (J:18161)

vision/eye
• arteriolar attenuation, venous dilation by 6 weeks (J:121993)
• severe retinal vessel attenuation and sheathing by 5 months (J:121993)
• arteriolar attenuation, venous dilation by 6 weeks (J:121993)
• severe retinal vessel attenuation and sheathing by 5 months (J:121993)
• granular appearance by 6 weeks (J:121993)
• focal and diffuse loss of pigment epithelium by 5 months (J:121993)
• granular appearance by 6 weeks (J:121993)
• focal and diffuse loss of pigment epithelium by 5 months (J:121993)
• reduced and disorganized nuclear layer by 3 weeks (J:121993)
• reduced and disorganized nuclear layer by 3 weeks (J:121993)
• a progressive loss of outer nuclear layers (J:121993)
• a progressive loss of outer nuclear layers (J:121993)
• contains at most one-third of thickness of cell in this layer compared to normal mice (J:26067)
• contains at most one-third of thickness of cell in this layer compared to normal mice (J:26067)
• no photoreceptors were present by 8 months (J:121993)
• no photoreceptors were present by 8 months (J:121993)
• are attenuated (J:26067)
• are attenuated (J:26067)
• composed of membranous whirls arranged in an irregular configuration (J:121993)
• normal organized photoreceptor cell outer segments are not observed at any time (J:121993)
• normal organized photoreceptor cell outer segments are not observed at any time (J:121993)
• composed of membranous whirls arranged in an irregular configuration (J:121993)
• largely degenerated (J:26067)
• largely degenerated (J:26067)
• a progressive loss of the photoreceptors (J:121993)
• a progressive loss of the photoreceptors (J:121993)
• develop progressive retinal degeneration (J:32415)
• develop progressive retinal degeneration (J:32415)
• pyknotic photoreceptor cell nuclei are observed throughout the first 15 weeks (J:121993)
• rate of photoreceptor loss was constant and both cone and rod photoreceptor cells are degenerated at equal pace (J:121993)
• the rate of degeneration was similar in both the peripheral and central region (J:121993)
• only one to two layers of photoreceptor cell nuclei remained at 15-16 postnatal weeks (J:121993)
• degenerative changes within the inner retina were not observed during first 15 postnatal weeks (J:121993)
• pyknotic photoreceptor cell nuclei are observed throughout the first 15 weeks (J:121993)
• rate of photoreceptor loss was constant and both cone and rod photoreceptor cells are degenerated at equal pace (J:121993)
• the rate of degeneration was similar in both the peripheral and central region (J:121993)
• only one to two layers of photoreceptor cell nuclei remained at 15-16 postnatal weeks (J:121993)
• degenerative changes within the inner retina were not observed during first 15 postnatal weeks (J:121993)
• patches of pigment deposits by 5 months (J:121993)
• patches of pigment deposits by 5 months (J:121993)
• the electroretinogram in homozygous mutant is never normal (J:121993)
• the waves are poorly developed and have reduced amplitudes compared to normal controls in the higher intensity waveforms (J:121993)
• with lower intensity flashes, the electroretinography exhibited lower amplitudes (J:121993)
• the amplitude loss was progressive and the electroretinogram was extinguished by 6 months (J:121993)
• the electroretinogram in homozygous mutant is never normal (J:121993)
• the waves are poorly developed and have reduced amplitudes compared to normal controls in the higher intensity waveforms (J:121993)
• with lower intensity flashes, the electroretinography exhibited lower amplitudes (J:121993)
• the amplitude loss was progressive and the electroretinogram was extinguished by 6 months (J:121993)

hearing/vestibular/ear
• at the basal end of the cochlea the osseous spiral lamina is partly empty, indicating loss of the afferent processes of the spiral ganglion cells (J:26067)
• at the basal end of the cochlea the osseous spiral lamina is partly empty, indicating loss of the afferent processes of the spiral ganglion cells (J:26067)
• a severely degenerated organ of Corti; no hair cells or supporting cells are identifiable (J:26067)
• a severely degenerated organ of Corti; no hair cells or supporting cells are identifiable (J:26067)
• apparent by 6 postnatal months (J:121993)
• apparent by 6 postnatal months (J:121993)
• only the innermost row of outer hair cells is seen, suggesting a partial loss of outer hair cells (J:26067)
• any reduction in the number of outer hair cells in the apical half of mutant cochlea at 5-6 months of age is modest (J:26067)
• only the innermost row of outer hair cells is seen, suggesting a partial loss of outer hair cells (J:26067)
• any reduction in the number of outer hair cells in the apical half of mutant cochlea at 5-6 months of age is modest (J:26067)
• apparent by 6 postnatal months (J:121993)
• apparent by 6 postnatal months (J:121993)
• a severely degenerated organ of Corti; no hair cells or supporting cells are identifiable (J:26067)
• a severely degenerated organ of Corti; no hair cells or supporting cells are identifiable (J:26067)
• degeneration of phalangeal and other support cells was also observed (J:121993)
• degeneration of phalangeal and other support cells was also observed (J:121993)
• a degeneration of organ of Corti in the basal end of the cochlea (J:26067)
• the transition from a well organized organ of Corti with at least a partial complement of inner and outer hair cells, to a mass of undifferentiated cells occurred in the lower basal turn (J:26067)
• apical half of the cochlea are normal with preservation of hair cells, supporting cells, and afferent dendrites (J:26067)
• the features of Reissner's membrane, stria vascularis, and the density of nerve fibers within the modiolus are normal (J:26067)
• Rosenthal's canal, is similar in appearance in all turns (J:26067)
• neither behavioral nor structural evidence of vestibular abnormalities (J:26067)
• a degeneration of organ of Corti in the basal end of the cochlea (J:26067)
• the transition from a well organized organ of Corti with at least a partial complement of inner and outer hair cells, to a mass of undifferentiated cells occurred in the lower basal turn (J:26067)
• apical half of the cochlea are normal with preservation of hair cells, supporting cells, and afferent dendrites (J:26067)
• the features of Reissner's membrane, stria vascularis, and the density of nerve fibers within the modiolus are normal (J:26067)
• Rosenthal's canal, is similar in appearance in all turns (J:26067)
• neither behavioral nor structural evidence of vestibular abnormalities (J:26067)
• some homozygous mutants showed elevated ABR thresholds to clicks and 32-kHz pips at 3 weeks of age (J:121993)
• at 7, 9, and 12 weeks of age, homozygous mutant mice exhibited 20- to 30-dB higher ABR thresholds across all stimuli at click, 8 kHz, 16 kHz, and 32 kHz (J:121993)
• some homozygous mutants showed elevated ABR thresholds to clicks and 32-kHz pips at 3 weeks of age (J:121993)
• at 7, 9, and 12 weeks of age, homozygous mutant mice exhibited 20- to 30-dB higher ABR thresholds across all stimuli at click, 8 kHz, 16 kHz, and 32 kHz (J:121993)
• progressive hearing loss, so that by 5-6 months of age, virtually deaf at 90-100 dB (J:121993)
• progressive hearing loss, so that by 5-6 months of age, virtually deaf at 90-100 dB (J:121993)

nervous system
• a severely degenerated organ of Corti; no hair cells or supporting cells are identifiable (J:26067)
• a severely degenerated organ of Corti; no hair cells or supporting cells are identifiable (J:26067)
• apparent by 6 postnatal months (J:121993)
• apparent by 6 postnatal months (J:121993)
• only the innermost row of outer hair cells is seen, suggesting a partial loss of outer hair cells (J:26067)
• any reduction in the number of outer hair cells in the apical half of mutant cochlea at 5-6 months of age is modest (J:26067)
• only the innermost row of outer hair cells is seen, suggesting a partial loss of outer hair cells (J:26067)
• any reduction in the number of outer hair cells in the apical half of mutant cochlea at 5-6 months of age is modest (J:26067)
• apparent by 6 postnatal months (J:121993)
• apparent by 6 postnatal months (J:121993)
• no photoreceptors were present by 8 months (J:121993)
• no photoreceptors were present by 8 months (J:121993)
• are attenuated (J:26067)
• are attenuated (J:26067)
• normal organized photoreceptor cell outer segments are not observed at any time (J:121993)
• composed of membranous whirls arranged in an irregular configuration (J:121993)
• normal organized photoreceptor cell outer segments are not observed at any time (J:121993)
• composed of membranous whirls arranged in an irregular configuration (J:121993)
• largely degenerated (J:26067)
• largely degenerated (J:26067)
• a progressive loss of the photoreceptors (J:121993)
• a progressive loss of the photoreceptors (J:121993)
• at the basal end of the cochlea the osseous spiral lamina is partly empty, indicating loss of the afferent processes of the spiral ganglion cells (J:26067)
• spiral ganglion cell bodies in Rosenthal's canal in the most basal half turn were lost in some cochlea (J:26067)
• at the basal end of the cochlea the osseous spiral lamina is partly empty, indicating loss of the afferent processes of the spiral ganglion cells (J:26067)
• spiral ganglion cell bodies in Rosenthal's canal in the most basal half turn were lost in some cochlea (J:26067)

pigmentation
• granular appearance by 6 weeks (J:121993)
• focal and diffuse loss of pigment epithelium by 5 months (J:121993)
• granular appearance by 6 weeks (J:121993)
• focal and diffuse loss of pigment epithelium by 5 months (J:121993)

cardiovascular system
• arteriolar attenuation, venous dilation by 6 weeks (J:121993)
• severe retinal vessel attenuation and sheathing by 5 months (J:121993)
• arteriolar attenuation, venous dilation by 6 weeks (J:121993)
• severe retinal vessel attenuation and sheathing by 5 months (J:121993)

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:32415


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory