Phenotypes Associated with This Genotype

Genotype
MGI:2174747

• Allelic Composition: Stat3^tm1Aki/Stat3^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological analysis of wild type and Stat3^tm1Aki/Stat3^tm1Aki embryos

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:40106 )

• homozygotes develop into the egg cylinder stage until E6.0 but start undergoing rapid degeneration at E6.5

• all homozygotes are completely resorbed by E7.5

embryo

decreased inner cell mass proliferation ( J:40106 )

• in culture, E3.5 mutant blastocysts exhibit a reduced ICM outgrowth relative to wild-type blastocysts

failure to gastrulate ( J:40106 )

• homozygotes die at ~E7.0, the day at which gastrulation initiates

decreased embryo size ( J:40106 )

• at E6.0, homozygoys mutant embryos are smaller than wild-type embryos

absent mesoderm ( J:40106 )

• homozygotes show absence of mesoderm formation between E6.5 and E7.5

growth/size/body

decreased embryo size ( J:40106 )

• at E6.0, homozygoys mutant embryos are smaller than wild-type embryos

cellular

decreased inner cell mass proliferation ( J:40106 )

• in culture, E3.5 mutant blastocysts exhibit a reduced ICM outgrowth relative to wild-type blastocysts