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Phenotypes Associated with This Genotype
Genotype
MGI:2174709
Allelic
Composition
Prnptm1Cwe/Prnptm1Cwe
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (32 available); any Prnp mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal behavior (J:472)
• no ataxia or Purkinje cell loss observed (J:67593)

nervous system
• after 12 months, copper levels in the brain fail to increase with age unlike in wild-type mice
• copper levels in the synaptosomes are decreased compared to in wild-type mice
• GABA(A) receptor-mediated fast inhibition is weaker in hippocampal slices of mutants than in wild-type mice, indicating impaired synaptic inhibition
• inhibitory postsynaptic currents (ipscs) have significantly slower rising phases and are slower
• fast inhibitory postsynaptic potentials (ipsps) appear weaker in hippocampal slices than in wild-type, however excitatory postsynaptic potentials are normal
• long term potentiation in CA1 of hippocampal slices is weaker in both the absence and presence of bicuculline

homeostasis/metabolism
• after 12 months, copper levels in the brain fail to increase with age unlike in wild-type mice
• copper levels in the synaptosomes are decreased compared to in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory