About   Help   FAQ
Phenotypes Associated with This Genotype
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm1Rsa mutation (0 available); any Pkd1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Renal cysts in embryonic and adult kidneys of Pkd1tm1Rsa/Pkd1+ mice

renal/urinary system
• microscopic cysts are seen throughout the nephron in about 50% of heterozygotes before 9 months of age and are detected as early as 3 months of age
• macroscopic cysts are occasionally seen in heterozygotes from 4 to 19 months of age
• cysts are often lined with hyperplastic or apoptotic cells

liver/biliary system
• liver cysts are occasionally seen in heterozygotes from 19 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 1; PKD1 173900 J:72238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory