Mouse Genome Informatics
ht
    Pkd1tm1Rsa/Pkd1+
involves: 129S4/SvJaeSor
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Renal cysts in embryonic and adult kidneys of Pkd1tm1Rsa/Pkd1+ mice

renal/urinary system
• microscopic cysts are seen throughout the nephron in about 50% of heterozygotes before 9 months of age and are detected as early as 3 months of age
• macroscopic cysts are occasionally seen in heterozygotes from 4 to 19 months of age
• cysts are often lined with hyperplastic or apoptotic cells

liver/biliary system
• liver cysts are occasionally seen in heterozygotes from 19 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:72238