About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2170004
Allelic
Composition
Pitx2tm1Sac/Pitx2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pitx2tm1Sac mutation (0 available); any Pitx2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• multiple pupillary openings are seen in about 10% of heterozygotes (J:51160)
• multiple pupillary openings are seen in about 10% of heterozygotes (J:51160)
• seen in about 10% of heterozygotes (J:51160)
• seen in about 10% of heterozygotes (J:51160)
• seen in about 10% of heterozygotes (J:51160)
• seen in about 10% of heterozygotes (J:51160)
• clouded lenses are seen in about 10% of heterozygotes (J:51160)
• clouded lenses are seen in about 10% of heterozygotes (J:51160)
• in 2 of about 30 heterozygotes small eyes are seen (J:51160)
• in 2 of about 30 heterozygotes small eyes are seen (J:51160)

craniofacial
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)

skeleton
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)

growth/size/body
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)
• in 2 of about 30 heterozygotes mal-occluded incisors are seen (J:51160)
• in 2 of about 30 heterozygotes body size is reduced to 1/3 that of wild-type (J:51160)
• in 2 of about 30 heterozygotes body size is reduced to 1/3 that of wild-type (J:51160)

Mouse Models of Human Disease
OMIM ID Ref(s)
Axenfeld-Rieger Syndrome, Type 1; RIEG1 180500 J:51160


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory