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Phenotypes Associated with This Genotype
Genotype
MGI:2168108
Allelic
Composition
Pax3Sp-2H/Pax3Sp-2H
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3Sp-2H mutation (2 available); any Pax3 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• rachischisis is observed along with other abnormalities

nervous system
• rachischisis is observed along with other abnormalities

muscle
• DiI injections into the 3 somites immediately adjacent to the forelimb bud between E9.25 and E9.5 reveal impaired cell migration with no cell moving more than 30 - 40 um from the site of injection
• at E12.5 expression of myogenin is absent from the forelimb buds (J:18227)
• limb buds from E11 embryos cultured for 4 days fail to generate any cells expressing early myogenic markers (desmin and sarcomeric myosin) (J:32016)
• however, cells from somites grafted into chick limbs are able to undergo myogenic differentiation (J:32016)
• at E9.25, premature termination of the dermamyotome at the same level as the ventral lip of the axial myotome with absence of any epithelial structure in the ventral portion

cellular
• DiI injections into the 3 somites immediately adjacent to the forelimb bud between E9.25 and E9.5 reveal impaired cell migration with no cell moving more than 30 - 40 um from the site of injection


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory