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Phenotypes Associated with This Genotype
Genotype
MGI:2166311
Allelic
Composition
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• average left ventricular weight of 46.2mg is significantly higher than control A/J and results from an increase in the end-diastolic dimension and a proportional increase in wall thickness

cardiovascular system
• average left ventricular weight of 46.2mg is significantly higher than control A/J and results from an increase in the end-diastolic dimension and a proportional increase in wall thickness
• average left ventricular shortening of 39.1 is significantly lower than the 47.1 in A/J mice
• aortic ejection time is significantly longer than in A/J mice
• average 433 beats per minute versus 524 in A/J
• average heart rate is approximately 50 beats per minute higher than that in A/J

immune system
• moderately susceptible to mouse-adapted SARS-CoV infection, including moderate and transient weight loss

endocrine/exocrine glands
• Background Sensitivity: the pineal gland is more flattened than that of CBA mice and there is a loss of volume associated with a loss of pinealocytes between 6 weeks and 10 months of age, when the pineal volume of CBA increases
• Background Sensitivity: the C57BL/6J pineal gland is melatonin deficient

muscle
• average left ventricular shortening of 39.1 is significantly lower than the 47.1 in A/J mice
• aortic ejection time is significantly longer than in A/J mice

nervous system
• Background Sensitivity: the pineal gland is more flattened than that of CBA mice and there is a loss of volume associated with a loss of pinealocytes between 6 weeks and 10 months of age, when the pineal volume of CBA increases
• Background Sensitivity: the C57BL/6J pineal gland is melatonin deficient

homeostasis/metabolism
• exercise time on a treadmill is significantly greater than that of A/J


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory