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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr2tm3Cxd
targeted mutation 3, Chu-Xia Deng
MGI:6406985
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fgfr2tm3Cxd/Fgfr2+
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:6415681
cn2
Fgfr2tm3Cxd/Fgfr2+
Tg(Col2a1-cre)1Xya/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6415627


Genotype
MGI:6415681
cn1
Allelic
Composition
Fgfr2tm3Cxd/Fgfr2+
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm3Cxd mutation (0 available); any Fgfr2 mutation (22 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• in the skull of 8-week old mice, about 4% linear distances are increased by over 5%
• in the skull of 4-week old mice, about 5% linear distances are shortened by over 5% but no linear distance is shortened by over 10%
• the dorsoventral height of caudal skulls is slightly increased and the mediolateral breadth is not affected
• however, mice show no changes in bone volume or bone volume ratio of calvarial bone
• skulls show mildly shortened nasal bone, with the length of the nasal bone decreased by 10% along the rostrocaudal axis in 4-week oldmice but no changes in 8-week old mice

nervous system
• the rostrocaudal length and dorsoventral height on caudal brain is increased, with a 5.3% increase in dorsoventral height

skeleton
• in the skull of 4-week old mice, about 5% linear distances are shortened by over 5% but no linear distance is shortened by over 10%
• in the skull of 8-week old mice, about 4% linear distances are increased by over 5%
• the dorsoventral height of caudal skulls is slightly increased and the mediolateral breadth is not affected
• however, mice show no changes in bone volume or bone volume ratio of calvarial bone
• skulls show mildly shortened nasal bone, with the length of the nasal bone decreased by 10% along the rostrocaudal axis in 4-week oldmice but no changes in 8-week old mice




Genotype
MGI:6415627
cn2
Allelic
Composition
Fgfr2tm3Cxd/Fgfr2+
Tg(Col2a1-cre)1Xya/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm3Cxd mutation (0 available); any Fgfr2 mutation (22 available)
Tg(Col2a1-cre)1Xya mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• 8-week old skulls show less malformation than 4-week old skulls
• the distance of the paired anterior zygoma is increased by 11.2% and 5.4% in 4- and 8-week old mice, respectively
• the distance between two lacrimal bones is increased by 9.4% in 4-week old mice and shows no changes in 8-week old mice
• the linear distances between the intersection of interparietal and occipital bones at the midline and the posterior palate are decreased 6.4% and 6.6% in 4- and 8-week old mice, respectively
• mice show growth disturbance in the cranial base by P14
• P3 mice show shortened sphenooccipital synchondroses
• 4-week old mice show rostrocaudally shortened, but dorsoventrally increased cranial cavity, indicating a dorsoventrally increased and rostrocaudally shortened brain
• shortened skull length at 4 weeks of age
• approximately 58% linear distances in the cranium are shortened by over 5%, 33% distances exhibit less than 5% shortening, and 9% distances show over 5% increases in 4-week old mice
• the length of the lateral neurocranium is decreased 10.2% and the width of the caudal neurocranium is increased by 5.5% in 4-week old mice
• the neurocranium is not reduced along the rostro-caudal axis and has no change along the medial-lateral axis in 8-week old mice
• shortened basioccipital bone
• shortened basisphenoid bone
• the breadth of the frontal bone is mildly increased by 5.4% in 4-week old mice
• the breadth of frontal bone shows no changes in 8-week old mice
• the length of the frontal bone is mildly decreased by 5.9% in 4-week old mice
• frontal processes of the maxilla are shortened by 13.9% in 4-week old mice
• frontal processes of the maxilla are shortened by 9.2% in 8-week old mice
• the parietal frontal process of the maxilla is decreased by 7.2% in 8-week old mice
• the premaxilla length is decreased by 9.3% in 4-week old mice
• the premaxilla length is reduced 11.2% in 8-week old mice
• maxilla length is decreased by 7.5% in 4-week old mice
• maxilla length is decreased by 8.7% in 8-week old mice
• abnormal nasal bone at 8 weeks of age
• the length of the nasal bone is decreased 13.6% in 4-week old mice
• the length of the nasal bone is decreased 12.5% in 8-week old mice
• the zygomatic bone is shortened by 21.2% in 4-week old mice
• zygomatic bone is shortened by 9.3% in 8-week old mice
• 8-week old mice show a less severe midfacial shape than 4-week old mice

growth/size/body
• 8-week old mice show a less severe midfacial shape than 4-week old mice

skeleton
• 8-week old skulls show less malformation than 4-week old skulls
• the distance of the paired anterior zygoma is increased by 11.2% and 5.4% in 4- and 8-week old mice, respectively
• the distance between two lacrimal bones is increased by 9.4% in 4-week old mice and shows no changes in 8-week old mice
• the linear distances between the intersection of interparietal and occipital bones at the midline and the posterior palate are decreased 6.4% and 6.6% in 4- and 8-week old mice, respectively
• mice show growth disturbance in the cranial base by P14
• P3 mice show shortened sphenooccipital synchondroses
• 4-week old mice show rostrocaudally shortened, but dorsoventrally increased cranial cavity, indicating a dorsoventrally increased and rostrocaudally shortened brain
• shortened skull length at 4 weeks of age
• approximately 58% linear distances in the cranium are shortened by over 5%, 33% distances exhibit less than 5% shortening, and 9% distances show over 5% increases in 4-week old mice
• the length of the lateral neurocranium is decreased 10.2% and the width of the caudal neurocranium is increased by 5.5% in 4-week old mice
• the neurocranium is not reduced along the rostro-caudal axis and has no change along the medial-lateral axis in 8-week old mice
• shortened basioccipital bone
• shortened basisphenoid bone
• the breadth of the frontal bone is mildly increased by 5.4% in 4-week old mice
• the breadth of frontal bone shows no changes in 8-week old mice
• the length of the frontal bone is mildly decreased by 5.9% in 4-week old mice
• frontal processes of the maxilla are shortened by 13.9% in 4-week old mice
• frontal processes of the maxilla are shortened by 9.2% in 8-week old mice
• the parietal frontal process of the maxilla is decreased by 7.2% in 8-week old mice
• the premaxilla length is decreased by 9.3% in 4-week old mice
• the premaxilla length is reduced 11.2% in 8-week old mice
• maxilla length is decreased by 7.5% in 4-week old mice
• maxilla length is decreased by 8.7% in 8-week old mice
• abnormal nasal bone at 8 weeks of age
• the length of the nasal bone is decreased 13.6% in 4-week old mice
• the length of the nasal bone is decreased 12.5% in 8-week old mice
• the zygomatic bone is shortened by 21.2% in 4-week old mice
• zygomatic bone is shortened by 9.3% in 8-week old mice
• bone volume is decreased in calvarial bone due to the rostrocaudally shortened skull, but not change in bone volume ratio is seen
• premature closure of coronal sutures in P3 mice

vision/eye

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acrocephalosyndactylia DOID:12960 OMIM:101200
J:286452





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory