About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-ACE2)AC63Ctkt
transgene insertion AC63, Chien-Te K Tseng
MGI:6402829
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(CAG-ACE2)AC63Ctkt/0 either: (involves: BALB/c * C3H/HeJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6 * C57BL/6J) MGI:6402831


Genotype
MGI:6402831
tg1
Allelic
Composition
Tg(CAG-ACE2)AC63Ctkt/0
Genetic
Background
either: (involves: BALB/c * C3H/HeJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6 * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice show increased susceptibility to infection with the Urbani strain of the severe acute respiratory syndrome coronavirus (SARS-CoV) than controls, showing a moderate but progressive weight loss until day 8, however all mice recover
• mice infected with a higher dose of SARS-CoV show progressive weight loss and clinical manifestations between day 3 and 4, with much higher viral titer in the lungs and low titers in the brain, however show signs of recovery between day 8 and 9 and completely recover in the ensuing month





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory